Collecting Information About Treatment Results for Patients With Cushing's Syndrome

Inclusion Criteria:

- Age 14 or older

- Active or treated Cushing's (due to pituitary, ectopic, or adrenal tumor)

- The diagnosis of CS will be made by the PI, based on the below Endocrine Society
guidelines, the patient's clinical presentation, and the PI's judgment.

° Diagnostic criteria for pituitary CD are according to the Endocrine Society
guidelines and include: Elevated 24-hour urinary free cortisol (UFC), normal or
elevated plasma ACTH, elevated midnight salivary cortisol levels, or classic
dexamethasone suppression testing for CD (morning cortisol > 5 ug/dL after 1 mg
overnight of classic 2-day low dose test) and a pituitary lesion on MRI. If patient
does not have any of these results, pathology of ACTH tumor may confirm presence of
disease.

- For pituitary patients, if the patient demonstrates non-classic testing or no
pituitary lesion is seen on MRI then petrosal sinus sampling or positive surgical
pathology will be used to confirm pituitary source of Cushing's. Clinical or
biochemical remission after surgery will also confirm pituitary source.

- Ectopic Cushing's will be confirmed by petrosal sinus sampling and appropriate imaging
tests, or positive surgical pathology.

- Adrenal Cushing's will be confirmed by a suppressed plasma ACTH value and
identification of an adrenal lesion on CT or MRI, or positive surgical pathology.

- In lieu of MRI, surgical, or laboratory reports, physician's assessment note including
mention of results will also be used as source for eligibility purposes.

Exclusion Criteria:

- Patients with a diagnosis of iatrogenic Cushing's.