Use of Pancreatic Enzymes in Short Bowel Syndrome

This is an interventional study of subjects with short bowel syndrome to determine if enteral
absorption improves following therapy with pancreatic enzymes. The study will assess enteral
absorption and nutritional status at baseline through a series of stool tests, blood tests,
and anthropometric measurements. Following approximately ten days of therapy with pancreatic
enzymes, the study will reassess enteral absorption.

Inclusion Criteria:

- history of a small bowel resection with subsequent dependence on parenteral nutrition
for at least three months

- age 4 years to 65 years

- usual state of health for the past two weeks with no medication changes

- able to participate in a study for about four weeks with four study visits

- able to take pancreatic enzyme medication orally

Exclusion Criteria:

- significant disease other than short bowel syndrome affecting the gastrointestinal
tract that impacts absorption or digestions

- motility disorder

- medications that directly alter fat absorption

- cholestatic liver disease defined as a serum conjugated bilirubin greater than 1.0
mg/dL, chronic renal failure, gout, or hyperuricemia

- history of a pork allergy

- women who are pregnant or lactating

- history of fibrosing colonopathy

Those subjects who are eligible for the malabsorption blood test (MBT) test will be
excluded if they have a history of a soy or safflower oil allergy.