Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer



Status:Recruiting
Conditions:Prostate Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/16/2019
Start Date:November 16, 2017
End Date:December 2030

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Phase III IGRT and SBRT vs IGRT and Hypofractionated IMRT for Localized Intermediate Risk Prostate Cancer

This randomized phase III trial studies how well stereotactic body radiation therapy works
compared to intensity-modulated radiation therapy in treating patients with stage IIA-B
prostate cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink
tumors. Stereotactic body radiation therapy is a specialized radiation therapy that sends
x-rays directly to the tumor using smaller doses over several days and may cause less damage
to normal tissue. Stereotactic body radiation therapy may work better in treating patients
with prostate cancer.

PRIMARY OBJECTIVES:

I. To determine whether stereotactic body radiation therapy (SBRT) can be shown to be
superior to hypofractionated intensity-modulated radiation therapy (IMRT) in terms of
genitourinary (GU) and gastrointestinal (GI) toxicity by having fewer patients that
experience a minimal important decline (MID) in urinary irritation/obstructive and bowel
Health Related Quality of Life (HRQOL) as measured by Expanded Prostate Cancer Index
Composite (EPIC)-26 at 24 months post completion of therapy.

SECONDARY OBJECTIVES:

I. To determine if SBRT (5 fractions of 7.25 Gy) is superior to hypofractionated IMRT (28
fractions of 2.5 Gy) as measured by disease free survival (DFS).

II. To determine whether SBRT can be shown to be superior to hypofractionated IMRT at 12 and
24 months post completion of therapy in terms of HRQOL by having fewer patients that
experience a minimal important decline (MID) bowel (12 months only) sexual, hormonal, urinary
irritation/obstructive (12 months only) and in urinary incontinence HRQOL as measured by
EPIC-26.

III. To determine if SBRT (5 fractions of 7.25 Gy) is superior to hypofractionated IMRT (28
fractions of 2.5 Gy) as measured by biochemical failure, overall survival, local failure,
prostate cancer specific survival, and distant metastases.

IV. To determine if prostate imaging-reporting and data system (PIRADS)version (v)2 = 4/5
disease is predictive for biochemical failure.

TERTIARY OBJECTIVES:

I. To determine whether a potentially more expensive therapy, SBRT, would be cost-effective
than standard hypofractionated IMRT as measured by the European Quality of Life Five
Dimension Five Level Scale Questionnaire (EQ-5D-5L).

II. To determine if disease characteristics captured on MRI can be used to predict which
patients will respond to SBRT versus hypofractionated IMRT.

III. Collect specimens for future translational research analyses.

OUTLINE: Patients are randomized into 1 of 2 arms.

ARM I: Patients undergo IMRT once daily for 5 fractions per week for 28 fractions over less
than 32 business days.

ARM II: Patients undergo SBRT at least every other day for 2-3 fractions per week for 5
fractions over less than 12 business days.

After completion of study treatment, patients are followed up every 6-12 months until death
or study termination.

Inclusion Criteria:

- Previously untreated (no local therapy such as surgery, radiation cryotherapy, HIFU,
etc.) localized adenocarcinoma of the prostate with the following clinical findings:

- Clinical stage by digital rectal exam of either T1c or T2a/b (limited to one side
of the gland); (American Joint Committee on Cancer [AJCC], version 7) or cT1a-c
or 2a or 2b,

- Stages T1a-T1b are eligible if patient underwent transurethral prostatic
resection (TURP), the patient must meet one of the following 3 criteria: 1)
Gleason score must be Gleason 7(3+4) with a PSA < 20 ng/mL, or 2) Gleason 6(3+3)
with a PSA > 10 ng/mL and < 20 ng/mL; (AJCC, version 7) or 3) Group Grade 1 or 2

- If patient is receiving a 5-alpha reductase inhibitor at the time of
enrollment the baseline PSA value may be double the initial value and the
medication should be discontinued but a washout period is not required to
eligible, a PSA drawn while still on the medicine must be:

- < 10 ng/mL if Gleason 7(3+4) (Note: This patient would be on
stratification level 1 if PSA < 5 ng/mL and stratification level 2 if
less than 10 ng/mL).

- > 5 ng/mL and less than 10 ng/mL for Gleason 6(3+3) (Note: This
patients would be on stratification level 3).

- Percent of submitted positive core biopsies must be < 50% of all sextants
(Sextant refers to the bilateral base, mid and apex of the gland and the left and
right, resulting in six sections or sextants. Biopsies may take 2 from each
sextant. If more than 12 are sampled, some may be from a targeted region possibly
with multiple cores to ensure adequate tissue.)

- NOTE: all cores from a targeted lesion will be counted as an N of 1 core for
calculating percent positive cores in total

- The prostate volume must be < 60 cc as reported at time of biopsy or by separate
measure with ultrasound or other imaging modalities including magnetic resonance
imaging (MRI) or computed tomography (CT) scan

- Patients in active surveillance who elect to be treated are eligible if they meet
protocol requirements

- History and physical including a digital rectal exam 60 days prior to registration

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1 60 days prior to
registration

- MRI of pelvis (compliant with PIRADSv2 guidelines) within 90 days prior to
registration

- Bone scan or sodium fluoride positron emission tomography (PET) scan within 90 days
prior to registration

- Charlson modified co-morbidity score =< 3 for patients under 60 and =< 4 for patients
60 and over 21 days prior to registration

- International prostate symptom score (IPSS) of < 15 21 days prior to registration

- The patient must provide study-specific informed consent prior to study entry

- Willingness and ability to complete the Expanded Prostate Cancer Index Composite
(EPIC-26) questionnaire

- Completion of all items of the EPIC-26 which will be data entered at registration 60
days prior to registration

- Only English, Spanish, and French-speaking patients are eligible to participate

Exclusion Criteria:

- Definitive clinical or radiologic evidence of metastatic disease; no nodal involvement
or evidence of metastatic disease allowed as defined by screening of the pelvis and a
bone scan or sodium fluoride PET scan

- Definitive T3 disease on MRI

- Prior or current invasive malignancy with current evidence of active disease within
the past 3 years

- Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a
different cancer is allowable; must be off treatment for at least 3 years; [applicable
only to studies that incorporate systemic therapy]

- Prior radiotherapy to the region of the study cancer that would result in overlap of
radiation therapy fields

- The use of hormonal therapy is not allowed; if the patient in on a 5-alpha reductase
inhibitor, then they should be stopped prior to treatment once enrolled onto the
study; no washout period is required for this study to participate

- Severe, active co-morbidity defined as follows:

- Human immunodeficiency virus (HIV) positive with CD4 count < 200
cells/microliter; Note that patients who are HIV positive are eligible, provided
they are under treatment with highly active antiretroviral therapy (HAART) and
have a CD4 count >= 200 cells/microliter within 30 days prior to registration;
Note also that HIV testing is not required for eligibility for this protocol

- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects;
note, however, that laboratory tests for liver function and coagulation
parameters are not required for entry into this protocol; (patients on Coumadin
or other blood thinning agents are eligible for this study)

- Contraindication to MRI

- Cardiac pacemaker or defibrillator

- Surgically implanted electrical devices such as spinal stimulation devices or
intracranial stimulation devices, cochlear implants, the presence of metallic
foreign bodies in the orbits, and incompatible old mechanical heart valves and
aneurysm clips
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Principal Investigator: R. J. Lee
Phone: 801-507-3950
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
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Murray, UT
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New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: James B. Yu
Phone: 203-785-5702
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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New Haven, CT
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New York, New York 10016
Principal Investigator: Peter B. Schiff
Phone: 212-263-4434
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New York, NY
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Newark, Delaware 19713
Principal Investigator: Gregory A. Masters
Phone: 302-623-4450
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Newark, DE
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4755 Ogletown-Stanton Road
Newark, Delaware 19718
302-733-1000
Principal Investigator: Gregory A. Masters
Phone: 302-623-4450
Christiana Care Health System - Christiana Hospital A 913-bed, 1.3-million-square-foot, modern facility in Newark, Delaware,...
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Newark, DE
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150 Kingsley Lane
Norfolk, Virginia 23505
Principal Investigator: William J. Irvin
Phone: 804-893-8611
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Norfolk, VA
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600 Gresham Dr
Norfolk, Virginia 23507
(757) 388-3000
Principal Investigator: Mark E. Shaves
Phone: 757-388-2406
Sentara Norfolk General Hospital Sentara Norfolk General Hospital is recognized as the number one ranked...
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Norfolk, VA
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940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
Principal Investigator: J. S. Thompson
Phone: 405-271-8777
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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Oklahoma City, OK
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Oshkosh, Wisconsin 54904
Principal Investigator: Robert R. Kohl
Phone: 920-831-8900
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Oshkosh, WI
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Overland Park, Kansas 66210
Principal Investigator: Xinglei Shen
Phone: 913-945-7552
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Overland Park, KS
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255 W Lancaster Ave
Paoli, Pennsylvania 19301
(484) 565-1000
Principal Investigator: Albert S. DeNittis
Phone: 484-476-2649
Paoli Memorial Hospital Paoli is recognized regionally and nationally for outstanding medical and surgical services,...
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Paoli, PA
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Peoria, Arizona 85381
Principal Investigator: Terry T. Lee
Phone: 623-773-2873
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Peoria, AZ
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Peoria, Illinois 61637
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
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Peoria, IL
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Petoskey, Michigan 49770
Principal Investigator: Neal H. Bhatt
Phone: 313-576-9790
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Petoskey, MI
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111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Robert B. Den
Phone: 215-955-6084
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
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Philadelphia, Pennsylvania 19114
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