A Study of ERY974 in Patient With Advanced Solid Tumors



Status:Active, not recruiting
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/8/2019
Start Date:August 2016
End Date:December 2019

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Phase 1 Dose Escalation and Cohort Expansion Study of ERY974, An Anti-Glypican3 (GPC3)/CD3 Bispecific Antibody, in Patients With Advanced Solid Tumors

This is the open label, multicenter Phase 1 study which consists of a dose escalation to
determine the maximum tolerated dose (MTD) and cohort expansion to obtain a preliminary
evaluation of anti-tumor activity. ERY974 is intravenously injected to patients with Glypican
3 positive advanced solid tumors until unacceptable toxicity or disease progression.


Inclusion Criteria:

- Male or female patient with Glypican 3 positive advanced solid tumor not amenable to
standard therapy or for which standard therapy is not available or not indicated

- Measurable tumor

- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1

- Adequate bone marrow, liver, and renal function

- Adequate coagulation status

Exclusion Criteria:

- Patients with more than a single brain metastasis ( >1 cm)

- Patients with acute or chronic infection

- Major surgery within 28 days

- Pregnant or lactating women

- Patients with interstitial pneumonitis

- Patients require regular ascites/pleural effusion drainage
We found this trial at
8
sites
Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
?
mi
from
Boston, MA
Click here to add this to my saved trials
Clinical Trial Facility in Detroit Michigan
Detroit, Michigan
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Clinical Trial Facility in Durham North Carolina
Durham, North Carolina
?
mi
from
Durham, NC
Click here to add this to my saved trials
Clinical Trial Facility in New York New York
New York, New York 10032
?
mi
from
New York, NY
Click here to add this to my saved trials
Clinical Trial Facility in Paris
Paris, 75231
?
mi
from
Paris,
Click here to add this to my saved trials
Clinical Trial Facility in Providence Rhode Island
Providence, Rhode Island
?
mi
from
Providence, RI
Click here to add this to my saved trials
Clinical Trial Facility in Tampa Florida
Tampa, Florida
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Clinical Trial Facility in Washington District of Columbia
Washington, District of Columbia
?
mi
from
Washington,
Click here to add this to my saved trials