Tylenol Levels in Bariatric Patients

This will be a descriptive study carried out by study staff from the anesthesiology
department. The patient population will include obese patients scheduled for robot-assisted
or laparoscopic bariatric surgery. There will be no change in our usual anesthetic care for
these patients. Volume of distribution and elimination half-life of acetaminophen in serum
samples are the primary measurements of the study. If detected, a significant reduction in
opioid requirements may lead to improved patient satisfaction and decreased opiate side
effects.

Inclusion Criteria:

- Patients older than 12, but younger than 21 years of age undergoing robotic assisted
or laparoscopic bariatric surgery

- American Society of Anesthesiologists Physical Status Classification System (ASA) I,
II or III

- Parent/guardian willing and able to give consent

- Patient willing to give assent, or consent

- Patients that are otherwise healthy at the discretion of the study staff

- Patients with BMI >95th percentile

Exclusion Criteria:

- Patients with severe right heart failure or severe asthma

- Patients with deficient hepatic function that can affect drug metabolism

- Systemic steroid use within the last 3 months

- Patients who have taken acetaminophen containing medications within 24 hours of
surgery date

- Patients younger than 12, but older than 21 years of age undergoing robotic assisted
or laparoscopic bariatric surgery

- Patients having other procedures in addition to robotic assisted or laparoscopic
bariatric surgery

- American Society of Anesthesiologists Physical Status Classification System (ASA) IV
and above

- Females testing positive for pregnancy

- Parent/guardian not willing and able to give assent, or consent

- Patient not willing to give assent, or consent

- Patients with BMI < 95th percentile