Cognitive Effects of Citicoline in Men and Women With Age-Associated Memory Impairment

This study is a 12-week, randomized, double-blind, placebo-controlled trial of citicoline in
healthy men and women with Age-Associated Memory Impairment. Cognitive assessments will be
performed to determine whether citicoline administration with supportive memory, compared to
placebo administration.

Inclusion Criteria:

- male or female, 50-85 years of age

- at least a high school diploma or the equivalent

- self-reported memory loss

- scores ≥24 on the Mini-Mental State Examination, ≥85 on the Kaufman Brief Intelligence
Test, Second Edition, ≤5 on the Geriatric Depression Scale, and 4, 3, or 2 on the
Spatial Span Test

- no health conditions that would prevent him or her from fulfilling the study
requirements on the basis of medical history and routine laboratory test results

Exclusion Criteria:

- color blind

- abnormal laboratory test results

- major medical or neurological illness

- female who is pregnant, planning to be pregnant during the study period

- requiring treatment with a drug which might obscure the action of the study treatment