Effects of Psyllium on Niacin Tolerability



Status:Completed
Conditions:High Cholesterol, Other Indications
Therapuetic Areas:Cardiology / Vascular Diseases, Other
Healthy:No
Age Range:18 - Any
Updated:12/14/2017
Start Date:March 2009
End Date:July 2011

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Trial Summary
Trial Overview
Inclusion Criteria

A Prospective Randomized, Open-Label, Crossover Study on the Effects of Psyllium on Niacin Tolerability

The purpose of this study is to determine whether psyllium is effective in reducing flushing
due to niacin and also to measure the effect of niacin on cholesterol levels.


Inclusion Criteria:

- Patients who are starting ER niacin for clinical indication by a healthcare provider

- No prior use of psyllium for the past 2 months

- No prior use of niacin for the past 3 months

- Ability to give informed consent

- Must be reachable by telephone

Exclusion Criteria:

- Known contraindications to ER niacin, aspirin or psyllium (including: presence of
nausea, vomiting, abdominal pain, intestinal obstruction, or fecal impaction; known
hypersensitivity to ER niacin, aspirin or psyllium; severe hepatic dysfunction,
transaminitis; history of gastrointestinal bleed attributable to aspirin induced
gastritis)

- Patient who are unable to perform assessment of flushing using the standardized scales
or questionnaires

- Patients who are pregnant
We found this trial at
1
site
VA West Los Angeles Medical Center
Los Angeles, California 90073
?
mi
from
Los Angeles, CA
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