PET/MRI to Enhance Precision Guidance in Head and Neck Radiation Treatment Planning
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/16/2018 |
| Start Date: | September 12, 2017 |
| End Date: | April 2020 |
| Contact: | Cancer Connect |
| Email: | cancerconnect@uwcarbone.wisc.edu |
| Phone: | 8006228922 |
The purpose of this study is to evaluate this new technology available at the University of
Wisconsin Carbone Cancer Center in the setting of head and neck cancer radiation treatment
planning. This study will also provide preliminary data critical to the development of
multi-parametric, multi-modality quantitative imaging biomarkers and data analysis models for
prediction of outcome in both tumors and normal tissue, which are essential for
patient-specific adaptive therapy.
All participants will undergo a diagnostic PET/CT and a Radiation Treatment Planning CT per
SOC procedures. In addition, all participants will undergo an additional imaging set
consisting of a PET/MRI. It is anticipated that most patients will undergo the PET/MRI on the
same day as their PET/CT negating the need for a second injection of the FDG radioisotope
used for SOC PET imaging. All patients will receive gadolinium contrast per SOC dosing
guidelines for the MRI portion of the PET/MRI. Both SOC MMRI pulse sequences and
investigational sequences will be utilized in this study.
Wisconsin Carbone Cancer Center in the setting of head and neck cancer radiation treatment
planning. This study will also provide preliminary data critical to the development of
multi-parametric, multi-modality quantitative imaging biomarkers and data analysis models for
prediction of outcome in both tumors and normal tissue, which are essential for
patient-specific adaptive therapy.
All participants will undergo a diagnostic PET/CT and a Radiation Treatment Planning CT per
SOC procedures. In addition, all participants will undergo an additional imaging set
consisting of a PET/MRI. It is anticipated that most patients will undergo the PET/MRI on the
same day as their PET/CT negating the need for a second injection of the FDG radioisotope
used for SOC PET imaging. All patients will receive gadolinium contrast per SOC dosing
guidelines for the MRI portion of the PET/MRI. Both SOC MMRI pulse sequences and
investigational sequences will be utilized in this study.
Inclusion Criteria:
- Participants with tumors of the head and neck region (nasal cavity, oral cavity,
pharynx, larynx, sinuses, salivary glands, and head and neck skin) who are candidates
for radiation treatment.
Exclusion Criteria:
- Contraindications for MRI: All patients will be screened with standard UWHC MRI
screening procedures:
- Any person with the following will be excluded: cardiac pacemaker, metal fragments in
or around the eye, venous umbrella, permanent eyeliner or permanent artificial
eyebrows.
Patents with the following potentially non-MRI compatible devices will undergo screening
using the standard UWHC MRI screening protocol by trained UWHC personnel: cardiac
pacemaker, heart valve replacement, intracranial aneurysm clips, middle ear, eye, joint, or
penile implants, joint replacements, implantable hearing aids, neurostimulator devices,
insulin pumps, shunts/stents, metal mesh/coil implants; metal plate/pin/screws/wires, or
any other metallic implants. Also patients with anatomical constraints limiting the
feasibility of MRI will be excluded.
- Issue of pregnancy: We will exclude all known pregnant females from the study to avoid
the potential risk of fetal injury upon exposure to the PET scan. Determination of
pregnancy will be based upon the standard screening procedures in place for radiation
therapy.
- Persons who are not fluent in English
- Anyone who can not provide written informed consent
We found this trial at
1
site
600 Highland Ave.
Madison, Wisconsin 53792
Madison, Wisconsin 53792
(608) 263-6400
Principal Investigator: Paul Harari, MD
Phone: 800-622-8922
University of Wisconsin Carbone Cancer Center UW Carbone Cancer Center holds the unique distinction of...
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