A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ)



Status:Recruiting
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:60 - 85
Updated:4/5/2019
Start Date:December 18, 2017
End Date:September 16, 2021
Contact:There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or
Email:ClinicalTrials.gov@lilly.com
Phone:1-317-615-4559

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Trial Summary
Trial Overview
Inclusion Criteria

Assessment of Safety, Tolerability and Efficacy of LY3002813 in Early Symptomatic Alzheimer's Disease

The purpose of this study is to evaluate the safety, tolerability and efficacy of LY3002813
in early symptomatic Alzheimer's disease.


Inclusion Criteria:

- Gradual and progressive change in memory function reported by participants or
informants for ≥ 6 months.

- MMSE score of 20 to 28 (inclusive) at baseline or an acceptable historical
flortaucipir PET scan within 6 months prior to baseline that meets the central read
criteria.

- Meet 18F flortaucipir PET scan criteria.

- Meet 18F florbetapir PET scan (central read) criteria.

Exclusion Criteria:

- Have a history of long QT syndrome.

- Have received treatment with a stable dose of an acetylcholinesterase inhibitor
(AChEI) and/or memantine for less than 2 months before randomization.

- Contraindication to MRI.
We found this trial at
58
sites
Advanced Memory Research Institute of New Jersey
Toms River, New Jersey 08755
Principal Investigator: Sanjiv K Sharma
Phone: 732-341-9500
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Bradenton Research Center
3924 9th Avenue West
Bradenton, Florida 34205
Principal Investigator: William McElveen
Phone: 941-708-0005
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Bradenton, FL
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Jacksonville Center for Clinical Research
4085 University Blvd S # 1
Jacksonville, Florida 32216
Principal Investigator: Carolyn M Tran
Phone: 904-730-0101
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Jacksonville, FL
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Compass Research LLC
100 West Gore St # 202
Orlando, Florida 32806
(407) 426-9299
Principal Investigator: Ira J Goodman
Phone: 407-426-9299
Compass Research LLC Compass Research is a clinical research company dedicated to testing new medications...
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Orlando, FL
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Rhode Island Hospital
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Principal Investigator: Brian R. Ott
Phone: 401-444-6440
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Intercoastal Medical Group
Sarasota, Florida 34232
Principal Investigator: Mauricio Concha
Phone: 941-203-3750
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Sarasota, FL
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Stedman Clinical Trials
3212 Cove Bend Drive
Tampa, Florida 33613
Principal Investigator: Mary Stedman
Phone: 813-971-8311
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Tampa, FL
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JEM Research Institute
Atlantis, Florida 33462
Principal Investigator: Mark A Goldstein
Phone: 561-968-2933
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Atlantis, FL
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Insight Clinical Trials, LLC
3570 Warrensville Center Road
Beachwood, Ohio 44122
Principal Investigator: Deborah Gould
Phone: 216-526-1843
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Beachwood, OH
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McLean Hospital
115 Mill St
Belmont, Massachusetts 02478
(617) 855-2000
Principal Investigator: BRENT FORESTER
Phone: 617-855-3622
McLean Hospital McLean Hospital is a comprehensive psychiatric hospital committed to providing easy access to...
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The Memory Clinic
Bennington, Vermont 05201
Principal Investigator: Cynthia Murphy
Phone: 802-447-1409
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Bennington, VT
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Behavioral Health Center Research
Charlotte, North Carolina 28211
Principal Investigator: Oleg Tcheremissine
Phone: 704-446-7504
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Charlotte, NC
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Great Lakes Clinical Trials
Chicago, Illinois 60640
Principal Investigator: Jeffrey S. Ross
Phone: 773-275-3500
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Chicago, IL
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Ohio State University Medical Center
Columbus, Ohio 43210
Principal Investigator: Douglas W. Scharre
Phone: 614-293-4969
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Columbus, OH
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Texas Neurology, PA
Dallas, Texas 75214
Principal Investigator: Charles F Greenfield
Phone: 2148273610258
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Dallas, TX
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Associated Neurologists, PC - Danbury
Danbury, Connecticut 06810
Principal Investigator: Samuel H Markind
Phone: 203-748-2551
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Neurology Diagnostics, Inc
Dayton, Ohio 45414
Principal Investigator: Joel Vandersluis
Phone: 937-224-8200
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Dayton, OH
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Brain Matters Research
Delray Beach, Florida 33445
Principal Investigator: Mark L Brody
Phone: 561-374-8461
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Delray Beach, FL
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Alexian Brothers Medical Center
Elk Grove Village, Illinois 60007
Principal Investigator: CONCETTA FORCHETTI
Phone: 847-593-8553
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Elk Grove Village, IL
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Cognition Health
100 Eisenhower Drive
Fairfax, Virginia 22031
Principal Investigator: James L Bicksel
Phone: 703-520-9703
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Fairfax, VA
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University of Kansas Hospital
Fairway, Kansas 66205
Principal Investigator: Jeffrey M. Burns
Phone: 913-588-0555
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Fairway, KS
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Neurology Center of North Orange County
Fullerton, California 92835
Principal Investigator: Anthony M Ciabarra
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Fullerton, CA
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Guilford Neurologic Associates, Inc.
Greensboro, North Carolina 27405
Principal Investigator: Pramod Sethi
Phone: 336-273-2511
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Greensboro, NC
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Infinity Clinical Research, LLC
Hollywood, Florida 33021
Principal Investigator: Harvey Schwartz
Phone: 954-366-0277
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Hollywood, FL
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Houston Methodist
Houston, Texas 77030
Principal Investigator: Joseph C Masdeu
Phone: 713-441-1150
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Houston, TX
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Josephson Wallack Munshower Neurology P.C
Indianapolis, Indiana 46256
Principal Investigator: Kristi George
Phone: 317-537-6060
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Indianapolis, IN
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Indiana University School of Medicine
340 W 10th St #6200
Indianapolis, Indiana 46202
(317) 274-3772
Principal Investigator: Jared Brosch
Phone: 317-963-7402
Indiana University School of Medicine With more than 2,000 students in 2013, the Indiana University...
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Irvine Clinical Research Center
Irvine, California 92618
Principal Investigator: Elly R Lee
Phone: 9497531663x226
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Irvine, CA
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Institute for Memory Impairment & Neurological Disorders
Irvine, California 92697
Principal Investigator: Joshua Grill
Phone: 949-824-3250
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Las Vegas Medical Research
Las Vegas, Nevada 89113
Principal Investigator: Bharat R Mocherla
Phone: 702-750-0222 EXT 102
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Merritt Island Medical Research
Merritt Island, Florida 32952
Principal Investigator: Gregory Kirk
Phone: 321-305-5015
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ActivMed Practices & Research
Methuen, Massachusetts 01844
Principal Investigator: Michael J McCartney
Phone: 978-655-7155
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Pharmax Research Clinic
Miami, Florida 33126
Principal Investigator: Jorge M Venereo
Phone: 305-262-4321
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Miami, FL
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Miami Jewish Health Systems
Miami, Florida 33137
Principal Investigator: Marc Agronin
Phone: 305-514-8535
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Suncoast Clinical Research, Inc.
New Port Richey, Florida 34652
Principal Investigator: Vikram Atit
Phone: 727-849-4131
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Pharmacology Research Institute
Newport Beach, California 92660
Principal Investigator: Nader Oskooilar
Phone: 949-752-7936
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Hoag Memorial Hospital
Newport Beach, California 92663
Principal Investigator: William R Shankle
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Newport Beach, CA
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Boston Center for Memory
Newton, Massachusetts 02459
Principal Investigator: Paul R. Solomon
Phone: 617-699-6927
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Newton, MA
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Bruyere Research Institute
Ottawa, Ontario
Principal Investigator: Andrew Frank
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Palm Beach Neurological Group
8895 North Military Trail
Palm Beach Gardens, Florida 33410
Principal Investigator: Michael Tuchman
Phone: 561-694-1010
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Banner Alzheimer'S Institute
Phoenix, Arizona 85006
Principal Investigator: David Anthony Weidman
Phone: 602-839-6631
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Donald S. Marks, M.D., P.C.
Plymouth, Massachusetts 02360
Principal Investigator: Donald Marks
Phone: 508-746-5060
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Quantum Laboratories
Pompano Beach, Florida 33064
Principal Investigator: Jose E De La Gandara
Phone: 954-786-7331
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Progressive Medical Research
Port Orange, Florida 32127
Principal Investigator: Alexander J White
Phone: 386-304-7070
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Port Orange, FL
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Butler Hospital
345 Blackstone Blvd
Providence, Rhode Island 02906
(401) 455-6200
Principal Investigator: Stephen P Salloway
Phone: 401-455-6403
Butler Hospital Founded in 1844, Butler Hospital is the state's only non-profit, free-standing psychiatric hospital...
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Raleigh Neurology Associates
Raleigh, North Carolina 27607
Principal Investigator: Bradley J Robottom
Phone: 919-782-3456
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Raleigh, NC
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National Clinical Research - Richmond, Inc.
Richmond, Virginia 23294
Principal Investigator: John K Scott
Phone: 804-672-2995
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Richmond, VA
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Washington University
Saint Louis, Missouri 63110
Principal Investigator: BARBARA SNIDER
Phone: 314-286-2523
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Pacific Research Network
San Diego, California 92103
Principal Investigator: Stephen Thein
Phone: 619-294-4302
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Sharp Mesa Vista Hospital
San Diego, California 92123
Principal Investigator: MICHAEL PLOPPER
Phone: 858-836-8355
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Syrentis Clinical Research
Santa Ana, California 92705
Principal Investigator: John Duffy
Phone: 7145423008301
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KI Health Partners, LLC d/b/a NE Inst. for Clin. Res.
Stamford, Connecticut 06905
Principal Investigator: Peter J McAllister
Phone: 203-914-1903
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Banner Sun Health Research Institute
Sun City, Arizona 85351
Principal Investigator: Edward Zamrini
Phone: 623-832-6530
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Sun City, AZ
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Axiom Research
Tampa, Florida 33609
Principal Investigator: SUSAN STEEN
Phone: 813-353-9613
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Tampa, FL
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Compass Research
The Villages, Florida 32162
Principal Investigator: Jay J Rubin
Phone: 352-261-0901
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Cotton O'Neil Clinic
Topeka, Kansas 66606
Principal Investigator: Katherine J Willingham
Phone: 785-354-9591
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Topeka, KS
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Abington Neurological Associates
Willow Grove, Pennsylvania 19090
Principal Investigator: David C Weisman
Phone: 215-957-9250
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Willow Grove, PA
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Piedmont Medical Research, LLC.
Winston-Salem, North Carolina 27103
Principal Investigator: Franklin Giles Crowell
Phone: 336-794-8165
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