Dexamethasone as an Immediate Intervention
| Status: | Withdrawn |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 12/16/2017 |
| Start Date: | January 2017 |
| End Date: | December 12, 2017 |
Dexamethasone as an Immediate Intervention to Reduce Long-Term Stress Responses
To determine if a single dose of dexamethasone (5 mg) administered in the first 12 hours
following a potentially traumatic event alters a) cortisol and FKBP5 RNA the next day in the
periphery measured in saliva; b) FKBP5 methylation by 1 month; c) executive functioning and
emotion regulation functioning; d) psychophysiological (heart rate, respiration, skin
conductance) in response cued reminders of the trauma; e) enhances the likelihood of
remission of PTSD symptom severity.
following a potentially traumatic event alters a) cortisol and FKBP5 RNA the next day in the
periphery measured in saliva; b) FKBP5 methylation by 1 month; c) executive functioning and
emotion regulation functioning; d) psychophysiological (heart rate, respiration, skin
conductance) in response cued reminders of the trauma; e) enhances the likelihood of
remission of PTSD symptom severity.
Inclusion Criteria:
- Adults 18-70 years
- Evidence of acute Post Traumatic Event (PTE) exposure defined by Diagnostic and
Statistical Manual criterion 'A'
- Evidence of a significant stress response defined by DSM V PTSD criterion 'B' and
meeting at least criteria for 'partial PTSD' or a minimum of 3 of 4 DSM V PTSD symptom
criterion
- Score of 60 or higher on the Subjective Units of Distress Scale (SUDS)
- Living in New York tri-state area
- Fluency in English, Spanish
Exclusion Criteria:
- Admission to an intensive care unit or other overnight admission
- In the Emergency Department for more than 6 hours
- Evidence of ongoing traumatic exposure (e.g. domestic violence)
- Evidence of psychotic symptoms
- Evidence of homicidality/suicidality
- Adults with an open head injury, a positive CT scan, loss of consciousness >30 seconds
or survivors in a coma
- Adults in police custody or Department of Correction (DOC) patients
- Inability to understand the study's procedures, risks, or side effects, or otherwise
unable to give informed consent.
- Females who are nursing or pregnant (as confirmed by a positive urine pregnancy test).
- Permanent cardiac pacer implant.
- . Self-reported medical conditions that may be affected by DEX including asthma,
epilepsy,diabetes, liver disease, kidney disease, thyroid disorder, muscle disorder,
history of malaria,tuberculosis, osteoporosis, glaucoma or cataracts.
- Self-reported adverse reactions to steroids
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