Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies

This is a Phase 1b/2, open label, multicenter, safety, clinical activity, pharmacokinetic
(PK), and pharmacodynamics (PD) study of avelumab in combination with chemotherapy with or
without other anti-cancer immunotherapies, as first-line treatment of adult patients with
locally advanced or metastatic solid tumors. Initially, avelumab will be evaluated in
combination with pemetrexed and carboplatin in patients with advanced non-squamous non-small
cell lung cancer (NSCLC) (Cohort A1) and with gemcitabine and cisplatin in patients with
cisplatin-eligible urothelial cancer (UC) (Cohort A2).

Given the growing preclinical and clinical indications that combinations of anti-cancer
immunotherapies potentially improve patient outcomes compared to results seen with single
agents, in portions of the study to be added in the future, avelumab will be evaluated in
combination with both standard-of-care chemotherapy and other anti-cancer immunotherapies in
patients with advanced malignancies. Each cohort in the study will consist of a Phase 1b
lead-in portion to evaluate safety and a Phase 2 cohort expansion to evaluate safety and
efficacy.

In the Phase 1b safety lead-in portion, up to 12 patients will be enrolled into each cohort
and evaluated for dose-limiting toxicities (DLT) during the first 2 cycles of treatment. If
investigational products administration in a cohort is deemed safe in the Phase 1b lead-in,
enrollment may be expanded into the Phase 2 cohort expansion. Up to approximately 40 patients
in each cohort (including those enrolled in the Phase 1b lead-in and those enrolled in the
Phase 2 cohort expansion) will be enrolled and treated with avelumab plus chemotherapy in the
initial portion of the study and, in future portions of the study, with avelumab plus
chemotherapy with or without other anti-cancer immunotherapies.

In the Phase 1b lead-in portions of NSCLC Cohort A1 and UC Cohort A2, avelumab is dosed at
800 mg fixed dose every 3 weeks. Under Protocol Amendment 4, avelumab is dosed at 1200 mg
fixed dose every 3 weeks in the Phase 1b lead-in portions of NSCLC Cohort A3 and in UC Cohort
A4, in combination with the same standard-of-care chemotherapy doublets used in Cohort A1 and
Cohort A2, respectively. For each tumor type, the study treatment combination with the
highest avelumab dose determined to be safe may be advanced into Phase 2 cohort expansion.

Inclusion Criteria:

1. Histological diagnosis of locally advanced (primary or recurrent) or metastatic solid
tumor that is not amenable for treatment with curative intent as follows:

- For all groups:

- Measurable disease by RECIST v1.1 with at least 1 measurable lesion, and
availability of tumor specimen 18 months or less old.

- No prior systemic treatment for unresectable locally advanced or metastatic
disease for the tumor type under study. If prior systemic chemotherapy treatment
was given in the adjuvant or neo-adjuvant setting or as part of radiotherapy
chemotherapy treatment, disease-free interval after stop of systemic treatment
must be more than 6 months for non-squamous NSCLC and more than 12 months for UC;

- Cohort A1 and Cohort A3: Non-squamous NSCLC, with no activating EGFR mutations,
ALK or ROS1 translocations/rearrangements. If monotherapy pembrolizumab is
available as a standard of care treatment option, patients must have a tumor
proportion score (TPS) <50% for PD L1 (via the 22C3 pharmDx or the Ventana
(SP263) PD L1 IHC assay).

- Cohort A2 and Cohort A4: Transitional cell carcinoma of the urothelium including
the bladder, urethra, renal pelvis, and ureter.

2. ECOG performance status 0 or 1

3. Estimated life expectancy of at least 90 days

4. Adequate bone marrow, renal, and liver function

5. Negative serum pregnancy test at screening

6. Signed and dated informed consent

Exclusion Criteria:

1. Prior immunotherapy with any antibody or drug specifically targeting T cell
co-stimulation or immune checkpoint pathways.

2. Patients with known symptomatic central nervous system metastases requiring steroids.

3. Diagnosis of other malignancy within 2 years prior to enrollment except adequately
treated basal cell or squamous cell skin cancer, or carcinoma in situ of the bladder,
breast, or cervix, or low grade (Gleason ≤6) prostate cancer

4. Use of immunosuppressive medication at the time of enrollment

5. Active or prior autoimmune disease that might deteriorate when receiving an
immuno-stimulatory agent.

6. Prior organ transplantation including allogenic stem cell transplantation

7. Active infection requiring systemic therapy

8. Known history of HIV or AIDS

9. Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection at screening

10. Administration of live vaccine within 4 weeks prior to study entry

11. Known prior severe hypersensitivity to the investigational products or any component
in their formulations,

12. Known prior severe hypersensitivity to platinum-related compounds for all cohorts, to
pemetrexed for patients enrolled in Cohort A1 and Cohort A3, and to gemcitabine for
patients enrolled in Cohort A2 and Cohort A4

13. Persisting toxicity related to prior therapy (NCI CTCAE v4.03 Grade > 1)

14. Known history of colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis.

15. Ongoing cardiac dysrhythmias of NCI CTCAE v4.03 Grade 2 or prolongation of the QTcF
interval to >480 msec.

16. Clinically significant (ie, active) cardiovascular disease: cerebral vascular
accident/stroke (<6 months prior to enrollment), myocardial infarction (< 6 months
prior to enrollment), unstable angina, congestive heart failure, or serious cardiac
arrhythmia requiring medication.

17. Major surgery ≤28 days or major radiation therapy ≤14 days prior to enrollment.

18. Participation in other studies involving investigational drug(s) within 28 days prior
to study entry.

19. Concurrent treatment with a prohibited medication.

20. Other acute or chronic medical or psychiatric condition

21. Pregnant female patients; breastfeeding female patients; fertile male patients and
female patients of childbearing potential who are unwilling or unable to use at least
1 highly effective method of contraception as outlined in this protocol for the
duration of the study and for at least 90 days after the last dose of chemotherapy
(for male and female patients) or at least 30 days after the last dose of avelumab
(for female patients), whichever is longer.