Functional Effects of Botox on the Brain Using MRS and fMRI
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 30 - 40 |
| Updated: | 2/7/2018 |
| Start Date: | September 30, 2017 |
| End Date: | November 1, 2017 |
Measuring the Functional Effects of Botox on the Brain Using MR Spectroscopy and fMRI
The injection of BOTOX into peripheral muscles has been shown to have therapeutic effects in
a growing number of indications including disorders involving skeletal muscle (e.g.,
strabismus, blepharospasm, cervical dystonia, spasticity, cosmetic), smooth muscle (e.g.,
bladder), glands (axillary hyperhidrosis) and nociceptive pain (e.g. migraine) (Brin. 2014).
Recently, several studies have suggested that peripheral BOTOX injections in the region of
the glabellar lines (muscles around the eyes) may be effective in treating major depression
and chronic migraine. However, the mechanism underlying the effect of peripheral BOTOX
injections on the brain is not well understood. Therefore, the Investigators propose to
further explore the functional effects of BOTOX injections on brain in healthy controls. The
approach will involve the measurement of brain metabolites in the brainstem using MRS as well
as an investigation of the functioning and connectivity between regions of the brain using
resting state MRI and high resolution fMRI.
a growing number of indications including disorders involving skeletal muscle (e.g.,
strabismus, blepharospasm, cervical dystonia, spasticity, cosmetic), smooth muscle (e.g.,
bladder), glands (axillary hyperhidrosis) and nociceptive pain (e.g. migraine) (Brin. 2014).
Recently, several studies have suggested that peripheral BOTOX injections in the region of
the glabellar lines (muscles around the eyes) may be effective in treating major depression
and chronic migraine. However, the mechanism underlying the effect of peripheral BOTOX
injections on the brain is not well understood. Therefore, the Investigators propose to
further explore the functional effects of BOTOX injections on brain in healthy controls. The
approach will involve the measurement of brain metabolites in the brainstem using MRS as well
as an investigation of the functioning and connectivity between regions of the brain using
resting state MRI and high resolution fMRI.
Participants will receive one MRI scan session prior to a standardized, clinical dose of
BOTOX injected into the forehead per FDA-approved procedures. Participants will then undergo
a second MRI scan session 2-3 weeks later, after the BOTOX has taken maximal effect.
Examining fMRI of the brainstem and the functional connectivity of the brainstem and
connections to cortex, may provide additional insight into the effects of BOTOX on neurologic
and psychiatric disorders.
BOTOX injected into the forehead per FDA-approved procedures. Participants will then undergo
a second MRI scan session 2-3 weeks later, after the BOTOX has taken maximal effect.
Examining fMRI of the brainstem and the functional connectivity of the brainstem and
connections to cortex, may provide additional insight into the effects of BOTOX on neurologic
and psychiatric disorders.
Inclusion Criteria:
- Females
- Ages 30-40 years of age
- Right-handed
- Normal or corrected-to-normal vision
- No history of psychiatric, neurological, or medical co-morbidities that might
interfere with normal brain functioning
- Fluent in English
- Moderate to severe glabellar lines
Exclusion Criteria:
- Pregnancy
- Ferrous metal, a pacemaker, or other battery-operated device implanted in the body
- Claustrophobia
- Known hypersensitivity to Botulinum Toxin
- Infection on the forehead or between the eyes
- Urinary tract infection
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