TU Tough: Mental Toughness Training for College Success

Part 1 will consist of an online survey, sent by email. This email will be sent through the
TU (University of Tulsa) Student Affairs office to all incoming freshman students and will
also be sent by study personnel to students who indicate interest in the study through the
other recruitment efforts (i.e., flyers on campus). This survey will also allow students to
indicate whether or not they would be interested in being involved in future research
regarding mental toughness and strategies for college success. The second aim will be
accomplished via Part 2 of the study. Part 2 is the longitudinal portion that assesses
students' well-being (i.e., happiness, distress, anxiety, satisfaction, etc.) and academic
success (i.e., retention at TU, GPA, etc.) before and after completion of either mental
toughness training or "college as usual". These participants will be selected from the group
of participants who complete Part 1 and/or via ongoing courses within each college at the
university (see recruitment section). Part 2 will enroll a maximum of 300 participants/year
for the first 3 years, each of whom will then be asked to remain in the study for 5 years.
These participants will be contacted via phone, text message, or email to determine whether
they are interested and meet criteria. Those who meet criteria will be scheduled for an
in-person session at TU (Part 2) to complete written informed consent, provide the saliva
sample, obtain instructions regarding the completion of survey sessions and the training
protocol. Those who enroll in this study will then be asked to complete survey sessions
repeatedly over the next 5 years: (1) During the first semester, Part 2 participants will be
asked to complete three survey sessions, one pre- and one post- training phase, and one
during finals week. (2) During the Spring semester of the first year, each participant would
complete three surveys (within the first two weeks; mid semester; and during finals week),
followed by one survey mid-Summer. (3) For Years 2-5, survey sessions would occur once per
semester (Fall, Spring, Summer), allowing examination of how training may impact longer-term
trajectories of academic success and psychological well-being. Each online surveys will
assess for psychological well-being, demographics and medical history, and academic
activities. For those who provide consent for us to access limited information from academic
records (as specified in the consent and in the research protocol section of this document),
the information will be combined with the collected survey data. For Part 3, data will be
collected from a subset of participants during two neuroimaging sessions at LIBR (Laureate
Institute for Brain Research). The first neuroimaging session will be completed within one
month of beginning the training phase (mental toughness or "college as usual") and the second
will be completed within one month of the end of the training phase. Each neuroimaging
session will last approximately 3-4 hours and will involve completion of self-report measures
regarding current affective state, a behavioral measure of exploratory behavior, and a
functional MRI session during which participants will complete tasks related to processing of
emotional faces, emotional images, and reward. The fourth aim will also be accomplished via
Part 2 of the study, which involves the collection of DNA saliva collection once during the
first semester of their first year. Samples will be collected in-person at their first
baseline session, after written informed consent is obtained. This data will be used to
assess any genetic markers of resiliency that exist in college populations and to determine
if there are genetic markers that interact with the impact of mental toughness training
(i.e., if individuals with specific genetic markers do better or worse with training).

Inclusion Criteria:

1. Age: 17 years old and over as of the first day of classes at TU for the year they are
being enrolled in the study. Due to this, all participants will be 18 years of age or
older when completing Year 2 of the longitudinal aspect of the study (Part 2,
Component B and C). A separate section concerning the inclusion of minors has been
included below.

2. Are an incoming first year student at the University of Tulsa

3. All genders

4. All races

5. Able to provide informed consent (or, if 17, to have their parents complete informed
consent and the minor complete informed assent).

6. Have sufficient proficiency in English language to understand and complete interviews,
questionnaires, and all other study procedures.

7. Have regular access to a personal, campus, or other computer on which to complete
online surveys.

8. For Part 3 only (neuroimaging portion), participants must have at least normative
levels of perceived stress (>21), as determined by the mean score from the initial
survey session completed under protocol 2015-010. This is to identify participants who
have the greatest potential to show demonstrable symptomatic change with mental
toughness training.

Exclusion Criteria (for Part 3, neuroimaging portion only):

1. Has a history of unstable liver or renal insufficiency; glaucoma; significant and
unstable cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic,
hematologic, rheumatologic, or metabolic disturbance; or any other condition that, in
the opinion of the investigator, would make participation not be in the best interest
(e.g., compromise the well-being) of the subject or that could prevent, limit, or
confound the protocol-specified assessments.

2. Current use of a medication that could potentially affect brain functioning (e.g.,
stimulants, antidepressants, anxiolytics, antipsychotics, mood stabilizers,
anti-hypertensives). Inclusion of individuals reporting other types of medications or
supplements not listed or considered thus far will be at the discretion of the PI
according to evidence in the literature of it affecting brain function or brain blood
flow.

3. MRI contraindications including: cardiac pacemaker, metal fragments in eyes/skin/body
(shrapnel), aortic/aneurysm clips, prosthesis, by-pass surgery/coronary artery clips,
hearing aid, heart valve replacement, shunt (ventricular or spinal), electrodes, metal
plates/pins/screws/wires, or neuro/bio-stimulators (TENS unit), persons who have ever
been a professional metal worker/welder, history of eye surgery/eyes washed out
because of metal, vision problems uncorrectable with lenses, inability to lie still on
one's back for 60-120 minutes; prior neurosurgery; tattoos or cosmetic makeup with
metal dyes, unwillingness to remove body piercings, and pregnancy.

4. Moderate to severe traumatic brain injury (>30 min. loss of consciousness or >24 hours
posttraumatic amnesia) or other neurocognitive disorder with evidence of neurological
deficits, neurological disorders, or severe or unstable medical conditions that might
be compromised by participation in the study (to be determined by primary care
provider)

5. Non-correctable vision or hearing problems