Study to Compare Pharmacokinetics & Pharmacodynamics of Warfarin & Esmolol in the Absence & Presence of MEDI0382

This is a Phase 1 open label, one-sequence, crossover study to evaluate the effect of
MEDI0382 on PK and PD of warfarin and esmolol in healthy subjects. The safety and
tolerability of MEDI0382 in combination with warfarin and esmolol will also be evaluated.
Following screening, the study consists of 2 5-day inpatient stays followed by outpatient
visits.

Inclusion Criteria:.

- Healthy volunteers aged ≥ 18 to 45 years

- BMI between 18 -30 kg/m2

- Females of childbearing potential who are sexually active with a nonsterilized male
partner must use at least one highly effective method of contraception

Exclusion Criteria:

- Any concurrent condition that in the opinion of the investigator would interfere with
the evaluation of the investigational product

- Receipt of investigational product as part of a clinical study or a GLP-1 analogue
containing preparation within the last 30 days or 5 half-lives of the drug (whichever
is longer) at the time of screening.

- Concurrent participation in another study of any kind

- Severe allergy/hypersensitivity to any of the proposed study treatments or excipients.

- History or presence of gastrointestinal (GI), hepatic, or renal disease or any other
conditions known to interfere with absorption, distribution, metabolism or excretion
of drugs.

- Impaired renal function is defined as estimated glomerular filtration rate (eGFR) < 60
mL/minute/1.73 m2 at screening.

- Any clinically significant illness, medical/surgical procedure, or trauma within 4
weeks of screening.

- History of hemophilia, von Willebrand's disease, lupus anticoagulant, or other
diseases/syndromes that can either alter or increase the propensity for bleeding.