Depth of Anesthesia on Implicit Memory
| Status: | Completed |
|---|---|
| Conditions: | Cognitive Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 55 - 90 |
| Updated: | 12/22/2017 |
| Start Date: | March 2006 |
| End Date: | January 2012 |
The Effect of Depth of Anesthesia on Implicit Memory
Purpose of this study is to see if different levels of anesthesia have an effect on hearing
spoken words without awareness of having heard them or anxiety after surgery.
spoken words without awareness of having heard them or anxiety after surgery.
Amnesia (lack of recall) is one of the most important goals of general anesthesia.
Inadvertent free recall during a major surgical procedure is not only inhumane, but also
predisposes the patient to morbidity such as post-traumatic stress disorder. Therefore, it is
standard practice among anesthesiologists to inquire about free (explicit) recall during a
post-anesthetic visit.
Free recall requires a functional long term memory. Historically, lack of free recall during
general anesthesia has been regarded as complete absence of long term memory activity.
However, recent evidence suggests that the relationship between general anesthesia and memory
is more complex than previously thought.
Objectives of the proposed are twofold: (1) to test the presence of implicit memory under two
different planes of surgical general anesthesia in elderly males (55-90 years old) during a
uniform surgical procedure (urologic procedures via transurethral approach) (2) to compare
the pre and postoperative anxiety levels as a marker of clinical significance of operational
implicit memory function.
The study is divided into three phases: pre-operative, operative, and post-operative.
Pre-operative phase will consist of a cognitive function test (mini-mental state exam). This
will be administered at the urology or pre-operative anesthesia clinic visit, after obtaining
the informed consent of the patient.
Operative phase will start with a baseline anxiety test (Spielberger state-trait anxiety
test) just before being taken to the operating room. This will be followed by playing an
audio file (a list of spoken words) via headphones under general anesthesia during the
surgical procedure.
Post-operative phase will have of a spoken word-stem completion test (just before discharge
from the hospital) and a repeat of the anxiety test mentioned above (2 to 3 weeks
post-operatively).
Inadvertent free recall during a major surgical procedure is not only inhumane, but also
predisposes the patient to morbidity such as post-traumatic stress disorder. Therefore, it is
standard practice among anesthesiologists to inquire about free (explicit) recall during a
post-anesthetic visit.
Free recall requires a functional long term memory. Historically, lack of free recall during
general anesthesia has been regarded as complete absence of long term memory activity.
However, recent evidence suggests that the relationship between general anesthesia and memory
is more complex than previously thought.
Objectives of the proposed are twofold: (1) to test the presence of implicit memory under two
different planes of surgical general anesthesia in elderly males (55-90 years old) during a
uniform surgical procedure (urologic procedures via transurethral approach) (2) to compare
the pre and postoperative anxiety levels as a marker of clinical significance of operational
implicit memory function.
The study is divided into three phases: pre-operative, operative, and post-operative.
Pre-operative phase will consist of a cognitive function test (mini-mental state exam). This
will be administered at the urology or pre-operative anesthesia clinic visit, after obtaining
the informed consent of the patient.
Operative phase will start with a baseline anxiety test (Spielberger state-trait anxiety
test) just before being taken to the operating room. This will be followed by playing an
audio file (a list of spoken words) via headphones under general anesthesia during the
surgical procedure.
Post-operative phase will have of a spoken word-stem completion test (just before discharge
from the hospital) and a repeat of the anxiety test mentioned above (2 to 3 weeks
post-operatively).
Inclusion Criteria:
- Persons signing informed consent
- Elective general surgery for orthopedics (external or internal fixation) or urologic
(transurethral)
- Literate
- Native English speaking
Exclusion Criteria:
- Hearing impaired
- History of cognitive dysfunction
- Subjects requiring post-operative sedation for any indication
We found this trial at
1
site
940 NE 13th St
Oklahoma City, Oklahoma 73190
Oklahoma City, Oklahoma 73190
(405) 271-6458
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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