Baclofen Treatment of Ataxia Telangiectasia
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 12 - Any |
| Updated: | 12/22/2017 |
| Start Date: | April 2007 |
| End Date: | February 2011 |
This research is being done to find out if Baclofen, a medicine that is often used for the
treatment of abnormal stiffness, might also be useful to treat some of the neurologic
problems caused by ataxia telangiectasia (A-T). The investigators also want to find out if
there are better ways to measure the problems of ataxia and abnormal eye movement for future
studies of medication in ataxia telangiectasia.
treatment of abnormal stiffness, might also be useful to treat some of the neurologic
problems caused by ataxia telangiectasia (A-T). The investigators also want to find out if
there are better ways to measure the problems of ataxia and abnormal eye movement for future
studies of medication in ataxia telangiectasia.
Inclusion Criteria:
- Teenagers over 12 years old and young adults with A-T may join if they have been
evaluated previously in the A-T Clinical Center at Johns Hopkins Hospital and have a
measurable abnormality of eye movement.
- Patients who are presently taking Baclofen will be eligible for the study if they are
presently receiving the medication under the direction of Dr. Crawford in the ATCC,
and are willing to withdraw from the medication for a period of one month prior to the
initial screening visit.
- Female patients who are sexually active will be given a standard serum HCG pregnancy
test.
- Those who are sexually active will be counseled about necessary precautions against
pregnancy during the duration of the trial.
Exclusion Criteria:
- A positive pregnancy test.
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