Prospective Analysis and Comparison of Stress Echo to Real-Time Myocardial Contrast Stress Echo

To compare two different stress echocardiograms (conventional Stress echocardiograms or
Real-time Myocardial Contrast Stress Echocardiograms) that are in routine clinical use. The
information, including the digital images that are collected during the stress tests is used
to determine if the usse of specialized imaging techniques and ultrasound contrast can better
detect blockage in blood flow to the heart and predict how patients outcome may be affected
by this detection of a blockage.

Inclusion Criteria:

- Male or female

- Age > 19 years

- Scheduled for a stress echocardiography

- Are conscious and coherent, and able to communicate effectively with trial personnel

- For troponin evaluation, only hospitalized patients who had a troponin level drawn in
the morning of and prior to stress echocardiogram will be included.

Exclusion Criteria:

- Pregnant and breast feeding women are excluded from participation because of the
possibility of a bias as CSE is routinely used in pregnant patients secondary to lack
of human studies to determine the fetal risk of use of Definity.

- Age < 19 years old

- Known or suspected hypersensitivity to ultrasound contrast agents or other drugs used
for the study

- Possibility that potential subject may be pregnant

- Studies where RT-MCE was specifically requested by the ordering physician