Venetoclax in Combination With Ublituximab and Umbralisib (TGR-1202) in Patients With Relapsed or Refractory CLL/SLL
| Status: | Recruiting |
|---|---|
| Conditions: | Blood Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/11/2018 |
| Start Date: | April 9, 2018 |
| End Date: | December 2021 |
| Contact: | TG Therapeutics Clinical Support Team |
| Email: | clinicalsupport@tgtxinc.com |
| Phone: | 212-554-4484 |
This study will be a standard 3+3 design with a lead in of umbralisib (TGR-1202) +
ublituximab for 12 weeks, i.e. 3 cycles, followed by venetoclax (20 mg - 200 mg) along with
umbralisib (TGR-1202) and ublituximab for patients with relapsed/refractory CLL.
ublituximab for 12 weeks, i.e. 3 cycles, followed by venetoclax (20 mg - 200 mg) along with
umbralisib (TGR-1202) and ublituximab for patients with relapsed/refractory CLL.
Inclusion Criteria:
- Confirmed diagnosis of B-cell Chronic Lymphocytic Leukemia
- Refractory to or relapsed after at least 1 prior treatment regimen
- Eastern Cooperative Oncology Group (ECOG) score of 0 to 2
Exclusion Criteria:
- Any major surgery, chemotherapy or immunotherapy within the last 21 days
- Known hepatitis B virus, hepatitis C virus or HIV infection
- Known histological transformation from CLL to an aggressive lymphoma (Richter's)
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Cleveland Clinic Taussig Cancer Center At Taussig Cancer Institute, more than 250 highly skilled doctors,...
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