A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies

Inclusion Criteria:

1. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

2. Presence of an active hematological malignancy.

3. Presence of measurable disease.

4. Hematological malignancy has been previously treated, has relapsed after or progressed
during prior therapy, and has limited potential for benefit from currently available
therapy including hematopoietic stem cell transplantation.

5. At least 2 weeks post any treatments/therapies at the time of first dose.

6. Adequate bone marrow function.

7. Adequate hepatic function.

8. Adequate renal function.

9. Normal coagulation panel.

10. Negative antiviral serology.

11. Willingness to use effective contraception.

Exclusion Criteria:

1. Central nervous system malignancy

2. Gastrointestinal disease

3. Significant cardiovascular disease

4. Significant ECG abnormalities.

5. Ongoing risk for bleeding due to active peptic ulcer disease, bleeding diathesis or
requirement for systemic anticoagulation

6. Ongoing systemic bacterial, fungal, or viral infection (including upper respiratory
tract infections)

7. Pregnancy or breastfeeding.

8. Major surgery within 4 weeks before the start of study therapy.

9. Ongoing immunosuppressive therapy, including systemic or enteric corticosteroids

10. Use of drugs that could prolong the QT interval within 7 days before the start of
study therapy.

11. Use of drugs that might pose a risk of a drug-drug interaction within 2-7 days before
the start of study therapy.