Safety and Tolerability of Oxymetazoline and Energy-Based Therapy in Participants With Rosacea

Inclusion Criteria:

-Documented clinical diagnosis of rosacea.

Exclusion Criteria:

- History of any of the following conditions: Raynaud's syndrome, narrow angle glaucoma,
orthostatic hypotension, cerebral or coronary insufficiency, thromboangiitis
obliterans, scleroderma, Sjögren's syndrome, severe or unstable or uncontrolled
cardiovascular disease, or any other current uncontrolled systemic disease

- Diagnosis or presence of any of the following conditions: rosaceaconglobata, rosacea
fulminans, isolated rhinophyma, isolated pustulosis of the chin, peri-oral dermatitis,
demodicidosis, facial keratosis pilaris, seborrheic dermatitis, acute lupus
erythematosus, or chronic recurring facial acne

- Current treatment with monoamine oxidase (MAO) inhibitors

- Current treatment with niacin ≥ 500 mg/day

- Greater than 3 inflammatory lesions on the face

- History or current evidence of drug or alcohol abuse within 12 months prior to the
screening visit.