The VetSeq Study: a Pilot Study of Genome Sequencing in Veteran Care

The VetSeq Study is a pilot intervention study exploring the feasibility of integrating
genome sequencing into clinical care at the VA Boston Healthcare System. Healthcare providers
may refer any patients who they think might benefit from diagnostic whole genome or exome
sequencing. Providers will briefly discuss genome sequencing and the pilot study with
potentially eligible patients. If a patient is interested, the provider will refer him/her to
the study by contacting the study staff and providing the reason (clinical question) why the
provider thinks genome sequencing might be beneficial for the patient. The study staff will
meet with the patient to conduct a baseline interview and survey, obtain informed consent for
sequencing, and obtain a blood specimen for sequencing. A clinical laboratory will perform
exome or whole-genome sequencing and issue an interpreted genome report including any variant
possibly explaining the patient's condition, in addition to secondary monogenic, carrier, and
pharmacogenomic results. This report will be sent to the referring provider, who will
document the results and associated decision-making in the medical record. Approximately 3
months later, study staff will conduct a follow-up interview and survey with the
participating patient.

Inclusion criteria:

- Patient referred by provider to study for genome sequencing

- Life expectancy of at least 12 months in the judgment of the referring provider

Exclusion criteria:

- Life expectancy of <12 months

- Inability to give informed consent