Pilot Study About Safety and Efficacy of Atomized Intrapleural Lidocaine During Pleuroscopy
| Status: | Withdrawn |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 12/27/2017 |
| Start Date: | February 2008 |
| End Date: | May 2010 |
A Pilot Study About Safety and Efficacy of Atomized Intrapleural Lidocaine During Pleuroscopy
This study will evaluate the potential to decrease the use of IV anesthesia drugs in patients
undergoing pleuroscopy administering lidocane standardly applied to the skin in combination
with atomized lidocaine applied into the pleural cavity.
undergoing pleuroscopy administering lidocane standardly applied to the skin in combination
with atomized lidocaine applied into the pleural cavity.
Most patient discomfort results from direct manipulation or contact with the parietal pleura
during chest tube placement, talc instillation or pleural biopsy. This study intends to use
combined IV, intradermal and intrapleural anesthesia during pleuroscopy procedures.
Intrapleural atomized lidocaine will be applied directly to the parital pleura. This study
will evaluate intravenous anesthesia reduction in subjects treated with intrapleural
lidocaine, reduction in total procedure timeby minimizing interruptions due to poor pain
control, reduce perioperative pain scores and improve patient comfort nad to determine safety
of fixed dosage of 3 mg/kg intrapleural lidocaine given during pleuroscopy.
during chest tube placement, talc instillation or pleural biopsy. This study intends to use
combined IV, intradermal and intrapleural anesthesia during pleuroscopy procedures.
Intrapleural atomized lidocaine will be applied directly to the parital pleura. This study
will evaluate intravenous anesthesia reduction in subjects treated with intrapleural
lidocaine, reduction in total procedure timeby minimizing interruptions due to poor pain
control, reduce perioperative pain scores and improve patient comfort nad to determine safety
of fixed dosage of 3 mg/kg intrapleural lidocaine given during pleuroscopy.
Inclusion Criteria:
- Patients diagnosed with pleural disease
- Patients undergoing pleuroscopy with talc with or w/o biopsy
- Patients aged 18 - 85
- Patients capable of signing informed consent
Exclusion Criteria:
- Severe congestive heart failure
- Hepatic failure, bilirubin > 2mg/dl, ALT,AST 3XULN
- Prior use Lidocaine in 48 hrs
- Hx SA drug reaction to lidocaine or amide local anesthetics
- Second or third degree heart block (w/o pacemaker)
- Sever sinoatrial block (w/o pacemaker)
- Concurrent treatment with quinidine, flecainide, dsopyramide, procainamide (ClassI
antirrhythmic agents)
- Prior use or amiodarone hydrochloride
- systolic BP < 90mmHg
- bradycardia
- accelerated idioventricular rhythm
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Lahey Clinic When Frank Lahey, MD, founded a group practice in 1923, his vision was...
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