In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 3/10/2019 |
| Start Date: | September 1, 2017 |
| End Date: | January 1, 2020 |
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells in Healthy Subjects Using Stable Isotope Resolved Metabolomics: A Pilot Study
This pilot study will first establish the feasibility of an in vivo methodology of assessing
the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from
healthy subjects while comparing it to an ex vivo approach
the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from
healthy subjects while comparing it to an ex vivo approach
Twenty healthy adult study participants between the ages of 18 and 60 years will be recruited
to participate in this pilot study that will include two groups: a) Ex Vivo group (10
volunteers) and b) In Vivo group (10 volunteers). Volunteers will be recruited to either
group in a sequential alternating fashion.
In vivo 13C SIRM studies evaluating the utilization of glutamine into the TCA cycle of normal
bone marrow plasma cells.
to participate in this pilot study that will include two groups: a) Ex Vivo group (10
volunteers) and b) In Vivo group (10 volunteers). Volunteers will be recruited to either
group in a sequential alternating fashion.
In vivo 13C SIRM studies evaluating the utilization of glutamine into the TCA cycle of normal
bone marrow plasma cells.
Inclusion Criteria:
- Ages 18-60
- Able to provide written consent
Exclusion Criteria:
- Renal Failure
- Pregnancy
- Active steroid use
- Active liver Disease
- Anemia (Hemoglobin < 12.5 g/dL in men and < 11.5 g/dL in women)
- H/O alcohol use (average > 2 drinks per day)
- BMI > 30
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