Dental Hygiene and Peri-Implant Tissues Homeostasis
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 25 - Any |
| Updated: | 12/29/2017 |
| Start Date: | November 22, 2017 |
| End Date: | May 15, 2019 |
| Contact: | Georgios Kotsakis, DDS, MS |
| Email: | kotsakis@uw.edu |
| Phone: | 206.616.9412 |
The Role of Dental Hygiene Procedures in Disruption of Healthy Homeostasis in Tissues Surrounding Dental Implants - Phase I
Dental implants have revolutionized the field of dentistry, providing improvements in
function and esthetics. They are not, however, without risks. Bone loss around implants (i.e.
periimplantitis) is an emerging public health concern. Untreated, peri-implantitis leads to
implant loss and jawbone defects. Nonetheless, existing therapies have failed to show
long-term efficacy. The pathogenesis of peri-implantitis is believed to be of bacterial
etiology similar to periodontal disease. Therefore, existing treatments duplicate strategies
for the treatment of natural teeth. However, the titanium (Ti) surface of implants is quite
dissimilar to teeth. Recent work from our lab has demonstrated that peri-implantitis is
associated with increased release of Ti particles around implants. These findings suggest
that treatments targeting periimplantitis must be designed around Ti material properties. A
gap in knowledge exists regarding the potential triggers of increased Ti dissolution from the
implant surface and the mechanisms by which Ti dissolution products amplify peri-implant
inflammation. The aim of this study is to determine if the use of tooth-driven treatment
approaches increase Ti in the submucosal plaque.
function and esthetics. They are not, however, without risks. Bone loss around implants (i.e.
periimplantitis) is an emerging public health concern. Untreated, peri-implantitis leads to
implant loss and jawbone defects. Nonetheless, existing therapies have failed to show
long-term efficacy. The pathogenesis of peri-implantitis is believed to be of bacterial
etiology similar to periodontal disease. Therefore, existing treatments duplicate strategies
for the treatment of natural teeth. However, the titanium (Ti) surface of implants is quite
dissimilar to teeth. Recent work from our lab has demonstrated that peri-implantitis is
associated with increased release of Ti particles around implants. These findings suggest
that treatments targeting periimplantitis must be designed around Ti material properties. A
gap in knowledge exists regarding the potential triggers of increased Ti dissolution from the
implant surface and the mechanisms by which Ti dissolution products amplify peri-implant
inflammation. The aim of this study is to determine if the use of tooth-driven treatment
approaches increase Ti in the submucosal plaque.
Inclusion Criteria:
- Is the subject ≥ 25 years of age?
- Does the subject have an implant with a probing depth ≥ 5mm, bleeding on probing, and
radiographic bone loss of > 2mm?
- Is the subject committed to the study and the required follow-up visits?
Exclusion Criteria:
- Is the subject immune compromised?
- Is the subject diabetic?
- Does the subject take steroid medication?
- Does the subject regularly use non-steroidal anti-inflammatories?
- Is the subject pregnant or intending to become pregnant during the duration of the
study?
- Has the subject had previous implantoplasty?
- Did the subject take any antibiotics in the last 3 months?
We found this trial at
1
site
Click here to add this to my saved trials
