Telmisartan (Micardis) and Ramipril (Altace) - Factorial Design Study for the Treatment of Hypertension



Status:Completed
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:12/30/2017
Start Date:April 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Double-dummy, Placebo-controlled, 3x4 Factorial Design Trial to Evaluate Telmisartan 20 and 80 mg Tablets in Combination With Ramipril 1.25, 10, and 20 mg Capsules After Eight Weeks of Treatment in Patients With Stage I or II Hypertension, With an ABPM Sub-study

To identify dose combinations of telmisartan and ramipril that are more effective in reducing
diastolic blood pressure than each of the respective monotherapies in patients with Stage I
or II hypertension.


Inclusion Criteria:

- Male and female patients >=18 years of age with Stage I or II hypertension defined as:

- a mean seated cuff diastolic blood pressure >=95 and <=119 mmHg Main

Exclusion Criteria:

- Pregnant

- breast-feeding

- unwilling to use birth control during the study

- secondary hypertension

- SBP>=180 mmHg

- DBP>=120 mmHg

- severe renal dysfunction

- hepatic insufficiency

- stroke within the last 6 months

- myocardial infarction, cardiac surgery, percutaneous transluminal coronary
angioplasty, unstable angina or coronary artery bypass graft within the past three
months

- unstable or uncontrolled diabetes

- history of angioedema of either of the study drugs, and hypersensitivity to the study
drugs.
We found this trial at
62
sites
Boehringer Ingelheim Investigational Site
Los Angeles, California
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Boehringer Ingelheim Investigational Site
Albuquerque, New Mexico
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Albuquerque, NM
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205.452.01364 Boehringer Ingelheim Investigational Site
Auburn, Maine
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Auburn, ME
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1245.20.10128 Boehringer Ingelheim Investigational Site
Avon, Indiana
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Avon, IN
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1245.28.10033 Boehringer Ingelheim Investigational Site
Blue Ridge, Georgia
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Blue Ridge, GA
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1237.5.01015 Boehringer Ingelheim Investigational Site
Boulder, Colorado
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Boulder, CO
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502.476.067 Boehringer Ingelheim Investigational Site
Buena Park, California
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Buena Park, CA
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1200.75.54005 Boehringer Ingelheim Investigational Site
Buenos Aires,
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Buenos Aires,
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1236.1.555 Boehringer Ingelheim Investigational Site
Cadillac, Michigan 49601
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Cadillac, MI
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1218.74.01105 Boehringer Ingelheim Investigational Site
Carrollton, Texas
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Carrollton, TX
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Boehringer Ingelheim Investigational Site
Cincinnati, Ohio
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Cincinnati, OH
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Boehringer Ingelheim Investigational Site
Columbus, Ohio
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Columbus, OH
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1264.3.01031 Boehringer Ingelheim Investigational Site
Concord, California
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Concord, CA
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205.452.01189 Boehringer Ingelheim Investigational Site
Corvallis, Oregon
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Corvallis, OR
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1236.1.534 Boehringer Ingelheim Investigational Site
Cumberland, Rhode Island
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Cumberland, RI
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1268.17.01045 Boehringer Ingelheim Investigational Site
Deland, Florida
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Deland, FL
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205.452.01038 Boehringer Ingelheim Investigational Site
Encinitas, California
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Encinitas, CA
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205.452.01323 Boehringer Ingelheim Investigational Site
Erie, Pennsylvania
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Erie, PA
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205.452.01341 Boehringer Ingelheim Investigational Site
Eugene, Oregon
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Eugene, OR
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1236.1.541 Boehringer Ingelheim Investigational Site
Excelsior Springs, Missouri 64024
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Excelsior Springs, MO
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1220.48.0043 Boehringer Ingelheim Investigational Site
Falls Church, Virginia
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Falls Church, VA
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1311.3.10103 Boehringer Ingelheim Investigational Site
Farmington, Connecticut
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Farmington, CT
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1301.1.5727 Boehringer Ingelheim Investigational Site
Glendale, Arizona
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Glendale, AZ
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1236.1.505 Ledeeach Family Medicine
658 Harleysville Pike
Harleysville, Pennsylvania 19438
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Harleysville, PA
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205.452.01269 Boehringer Ingelheim Investigational Site
Haverhill, Massachusetts
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Haverhill, MA
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205.452.01209 Boehringer Ingelheim Investigational Site
Hialeah, Florida
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Hialeah, FL
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Boehringer Ingelheim Investigational Site
Houston, Texas
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Houston, TX
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1236.1.546 River Cities Cardiology Research Inst of Middle America
41 Quartermaster Court
Jeffersonville, Indiana 47130
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Jeffersonville, IN
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205.452.01184 Boehringer Ingelheim Investigational Site
Jupiter, Florida
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Jupiter, FL
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1245.25.10156 Boehringer Ingelheim Investigational Site
Kettering, Ohio
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Kettering, OH
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1160.128.1054 Boehringer Ingelheim Investigational Site
Largo, Florida
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Largo, FL
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1218.61.01052 Boehringer Ingelheim Investigational Site
Las Vegas, Nevada
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Las Vegas, NV
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1199.14.1181 Boehringer Ingelheim Investigational Site
Long Beach, California
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Long Beach, CA
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1199.14.1186 Boehringer Ingelheim Investigational Site
Madison, Wisconsin
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Madison, WI
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1245.28.10020 Boehringer Ingelheim Investigational Site
Medford, Oregon
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Medford, OR
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502.476.106 Boehringer Ingelheim Investigational Site
Menomonee Falls, Wisconsin
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Menomonee Falls, WI
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1218.61.01040 Boehringer Ingelheim Investigational Site
Meridian, Idaho
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Meridian, ID
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1236.1.503 Anchor Research Center
15205 Collier Boulevard
Naples, Florida 34119
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Naples, FL
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1199.14.1057 Boehringer Ingelheim Investigational Site
New Port Richey, Florida
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New Port Richey, FL
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1245.23.10157 Boehringer Ingelheim Investigational Site
Newton, Kansas
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Newton, KS
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1222.29.11004 Boehringer Ingelheim Investigational Site
North Dartmouth, Massachusetts
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North Dartmouth, MA
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1218.64.10018 Boehringer Ingelheim Investigational Site
Pembroke Pines, Florida
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Pembroke Pines, FL
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1200.43.00106 Boehringer Ingelheim Investigational Site
Peoria, Illinois
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Peoria, IL
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Boehringer Ingelheim Investigational Site
Portland, Oregon
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Portland, OR
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1236.1.566 Boehringer Ingelheim Investigational Site
Richmond, Kentucky
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Richmond, KY
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1218.83.11014 Boehringer Ingelheim Investigational Site
Roseville, California
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Roseville, CA
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205.452.01001 Boehringer Ingelheim Investigational Site
Salt Lake City, Utah
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Salt Lake City, UT
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Boehringer Ingelheim Investigational Site
San Antonio, Texas
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502.476.097 Boehringer Ingelheim Investigational Site
Sandy, Utah
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Boehringer Ingelheim Investigational Site
Spartanburg, South Carolina
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Spartanburg, SC
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9.197.001 Boehringer Ingelheim Investigational Site
Tempe, Arizona
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1236.1.570 Boehringer Ingelheim Investigational Site
The Colony, Texas
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The Colony, TX
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1245.25.10162 Boehringer Ingelheim Investigational Site
Tipton, Pennsylvania
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Tipton, PA
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1236.1.525 Physicians Research Center, LLC, Toms River
9 Mule Road
Toms River, New Jersey 08755
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Toms River, NJ
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205.452.01221 Boehringer Ingelheim Investigational Site
Troy, Michigan
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Troy, MI
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1268.17.01043 Boehringer Ingelheim Investigational Site
Tucson, Arizona
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205.452.01307 Boehringer Ingelheim Investigational Site
Tulsa, Oklahoma
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Tulsa, OK
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205.452.01362 Boehringer Ingelheim Investigational Site
Tustin, California
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Tustin, CA
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1245.25.10206 Boehringer Ingelheim Investigational Site
Valparaiso, Indiana
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Valparaiso, IN
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1236.1.561 Clinical Research Center of Cape Cod
131 Attucks Lane
West Yarmouth, Massachusetts 02601
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West Yarmouth, MA
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1218.74.01069 Boehringer Ingelheim Investigational Site
Westlake Village, California
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Westlake Village, CA
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1199.14.1097 Boehringer Ingelheim Investigational Site
Wichita, Kansas
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Wichita, KS
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