Telmisartan (Micardis) and Ramipril (Altace) - Factorial Design Study for the Treatment of Hypertension



Status:Completed
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:12/30/2017
Start Date:April 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Double-dummy, Placebo-controlled, 3x4 Factorial Design Trial to Evaluate Telmisartan 20 and 80 mg Tablets in Combination With Ramipril 1.25, 10, and 20 mg Capsules After Eight Weeks of Treatment in Patients With Stage I or II Hypertension, With an ABPM Sub-study

To identify dose combinations of telmisartan and ramipril that are more effective in reducing
diastolic blood pressure than each of the respective monotherapies in patients with Stage I
or II hypertension.


Inclusion Criteria:

- Male and female patients >=18 years of age with Stage I or II hypertension defined as:

- a mean seated cuff diastolic blood pressure >=95 and <=119 mmHg Main

Exclusion Criteria:

- Pregnant

- breast-feeding

- unwilling to use birth control during the study

- secondary hypertension

- SBP>=180 mmHg

- DBP>=120 mmHg

- severe renal dysfunction

- hepatic insufficiency

- stroke within the last 6 months

- myocardial infarction, cardiac surgery, percutaneous transluminal coronary
angioplasty, unstable angina or coronary artery bypass graft within the past three
months

- unstable or uncontrolled diabetes

- history of angioedema of either of the study drugs, and hypersensitivity to the study
drugs.
We found this trial at
62
sites
205.452.01209 Boehringer Ingelheim Investigational Site
Hialeah, Florida
1314
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Hialeah, FL
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Boehringer Ingelheim Investigational Site
Albuquerque, New Mexico
523
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Albuquerque, NM
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205.452.01364 Boehringer Ingelheim Investigational Site
Auburn, Maine
1497
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Auburn, ME
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1245.20.10128 Boehringer Ingelheim Investigational Site
Avon, Indiana
630
mi
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Avon, IN
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1245.28.10033 Boehringer Ingelheim Investigational Site
Blue Ridge, Georgia
776
mi
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Blue Ridge, GA
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1237.5.01015 Boehringer Ingelheim Investigational Site
Boulder, Colorado
430
mi
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Boulder, CO
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502.476.067 Boehringer Ingelheim Investigational Site
Buena Park, California
1159
mi
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Buena Park, CA
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1200.75.54005 Boehringer Ingelheim Investigational Site
Buenos Aires,
5602
mi
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Buenos Aires,
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1236.1.555 Boehringer Ingelheim Investigational Site
Cadillac, Michigan 49601
786
mi
from
Cadillac, MI
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1218.74.01105 Boehringer Ingelheim Investigational Site
Carrollton, Texas
334
mi
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Carrollton, TX
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Boehringer Ingelheim Investigational Site
Cincinnati, Ohio
726
mi
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Cincinnati, OH
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Boehringer Ingelheim Investigational Site
Columbus, Ohio
810
mi
from
Columbus, OH
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1264.3.01031 Boehringer Ingelheim Investigational Site
Concord, California
1316
mi
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Concord, CA
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205.452.01189 Boehringer Ingelheim Investigational Site
Corvallis, Oregon
1397
mi
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Corvallis, OR
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1236.1.534 Boehringer Ingelheim Investigational Site
Cumberland, Rhode Island
1423
mi
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Cumberland, RI
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1268.17.01045 Boehringer Ingelheim Investigational Site
Deland, Florida
1124
mi
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Deland, FL
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205.452.01038 Boehringer Ingelheim Investigational Site
Encinitas, California
1141
mi
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Encinitas, CA
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205.452.01323 Boehringer Ingelheim Investigational Site
Erie, Pennsylvania
984
mi
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Erie, PA
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205.452.01341 Boehringer Ingelheim Investigational Site
Eugene, Oregon
1382
mi
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Eugene, OR
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1236.1.541 Boehringer Ingelheim Investigational Site
Excelsior Springs, Missouri 64024
223
mi
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Excelsior Springs, MO
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1220.48.0043 Boehringer Ingelheim Investigational Site
Falls Church, Virginia
1119
mi
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Falls Church, VA
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1311.3.10103 Boehringer Ingelheim Investigational Site
Farmington, Connecticut
1352
mi
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Farmington, CT
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1301.1.5727 Boehringer Ingelheim Investigational Site
Glendale, Arizona
856
mi
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Glendale, AZ
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1236.1.505 Ledeeach Family Medicine
658 Harleysville Pike
Harleysville, Pennsylvania 19438
1212
mi
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Harleysville, PA
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205.452.01269 Boehringer Ingelheim Investigational Site
Haverhill, Massachusetts
1445
mi
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Haverhill, MA
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Boehringer Ingelheim Investigational Site
Houston, Texas
569
mi
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Houston, TX
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1236.1.546 River Cities Cardiology Research Inst of Middle America
41 Quartermaster Court
Jeffersonville, Indiana 47130
658
mi
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Jeffersonville, IN
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205.452.01184 Boehringer Ingelheim Investigational Site
Jupiter, Florida
1272
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Jupiter, FL
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1245.25.10156 Boehringer Ingelheim Investigational Site
Kettering, Ohio
747
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Kettering, OH
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1160.128.1054 Boehringer Ingelheim Investigational Site
Largo, Florida
1103
mi
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Largo, FL
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1218.61.01052 Boehringer Ingelheim Investigational Site
Las Vegas, Nevada
960
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Las Vegas, NV
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1199.14.1181 Boehringer Ingelheim Investigational Site
Long Beach, California
1172
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Long Beach, CA
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Boehringer Ingelheim Investigational Site
Los Angeles, California
1168
mi
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Los Angeles, CA
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1199.14.1186 Boehringer Ingelheim Investigational Site
Madison, Wisconsin
575
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Madison, WI
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1245.28.10020 Boehringer Ingelheim Investigational Site
Medford, Oregon
1357
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Medford, OR
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502.476.106 Boehringer Ingelheim Investigational Site
Menomonee Falls, Wisconsin
632
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Menomonee Falls, WI
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1218.61.01040 Boehringer Ingelheim Investigational Site
Meridian, Idaho
1050
mi
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Meridian, ID
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1236.1.503 Anchor Research Center
15205 Collier Boulevard
Naples, Florida 34119
1230
mi
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Naples, FL
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1199.14.1057 Boehringer Ingelheim Investigational Site
New Port Richey, Florida
1091
mi
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New Port Richey, FL
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1245.23.10157 Boehringer Ingelheim Investigational Site
Newton, Kansas
33
mi
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Newton, KS
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1222.29.11004 Boehringer Ingelheim Investigational Site
North Dartmouth, Massachusetts
1445
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North Dartmouth, MA
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1218.64.10018 Boehringer Ingelheim Investigational Site
Pembroke Pines, Florida
1306
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Pembroke Pines, FL
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1200.43.00106 Boehringer Ingelheim Investigational Site
Peoria, Illinois
485
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Peoria, IL
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Boehringer Ingelheim Investigational Site
Portland, Oregon
1383
mi
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Portland, OR
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1236.1.566 Boehringer Ingelheim Investigational Site
Richmond, Kentucky
738
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Richmond, KY
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1218.83.11014 Boehringer Ingelheim Investigational Site
Roseville, California
1271
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Roseville, CA
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205.452.01001 Boehringer Ingelheim Investigational Site
Salt Lake City, Utah
779
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Salt Lake City, UT
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Boehringer Ingelheim Investigational Site
San Antonio, Texas
576
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San Antonio, TX
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502.476.097 Boehringer Ingelheim Investigational Site
Sandy, Utah
?
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Sandy, UT
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Boehringer Ingelheim Investigational Site
Spartanburg, South Carolina
903
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Spartanburg, SC
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9.197.001 Boehringer Ingelheim Investigational Site
Tempe, Arizona
846
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Tempe, AZ
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1236.1.570 Boehringer Ingelheim Investigational Site
The Colony, Texas
326
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The Colony, TX
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1245.25.10162 Boehringer Ingelheim Investigational Site
Tipton, Pennsylvania
1062
mi
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Tipton, PA
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1236.1.525 Physicians Research Center, LLC, Toms River
9 Mule Road
Toms River, New Jersey 08755
1274
mi
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Toms River, NJ
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205.452.01221 Boehringer Ingelheim Investigational Site
Troy, Michigan
841
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Troy, MI
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1268.17.01043 Boehringer Ingelheim Investigational Site
Tucson, Arizona
835
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205.452.01307 Boehringer Ingelheim Investigational Site
Tulsa, Oklahoma
149
mi
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Tulsa, OK
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205.452.01362 Boehringer Ingelheim Investigational Site
Tustin, California
1152
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1245.25.10206 Boehringer Ingelheim Investigational Site
Valparaiso, Indiana
627
mi
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Valparaiso, IN
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1236.1.561 Clinical Research Center of Cape Cod
131 Attucks Lane
West Yarmouth, Massachusetts 02601
1480
mi
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West Yarmouth, MA
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1218.74.01069 Boehringer Ingelheim Investigational Site
Westlake Village, California
1197
mi
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Westlake Village, CA
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1199.14.1097 Boehringer Ingelheim Investigational Site
Wichita, Kansas
26
mi
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Wichita, KS
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