Telmisartan (Micardis) and Ramipril (Altace) - Factorial Design Study for the Treatment of Hypertension



Status:Completed
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:12/30/2017
Start Date:April 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Double-dummy, Placebo-controlled, 3x4 Factorial Design Trial to Evaluate Telmisartan 20 and 80 mg Tablets in Combination With Ramipril 1.25, 10, and 20 mg Capsules After Eight Weeks of Treatment in Patients With Stage I or II Hypertension, With an ABPM Sub-study

To identify dose combinations of telmisartan and ramipril that are more effective in reducing
diastolic blood pressure than each of the respective monotherapies in patients with Stage I
or II hypertension.


Inclusion Criteria:

- Male and female patients >=18 years of age with Stage I or II hypertension defined as:

- a mean seated cuff diastolic blood pressure >=95 and <=119 mmHg Main

Exclusion Criteria:

- Pregnant

- breast-feeding

- unwilling to use birth control during the study

- secondary hypertension

- SBP>=180 mmHg

- DBP>=120 mmHg

- severe renal dysfunction

- hepatic insufficiency

- stroke within the last 6 months

- myocardial infarction, cardiac surgery, percutaneous transluminal coronary
angioplasty, unstable angina or coronary artery bypass graft within the past three
months

- unstable or uncontrolled diabetes

- history of angioedema of either of the study drugs, and hypersensitivity to the study
drugs.
We found this trial at
62
sites
1218.83.11014 Boehringer Ingelheim Investigational Site
Roseville, California
2607
mi
from 02139
Roseville, CA
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Boehringer Ingelheim Investigational Site
Albuquerque, New Mexico
1965
mi
from 02139
Albuquerque, NM
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205.452.01364 Boehringer Ingelheim Investigational Site
Auburn, Maine
127
mi
from 02139
Auburn, ME
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1245.20.10128 Boehringer Ingelheim Investigational Site
Avon, Indiana
815
mi
from 02139
Avon, IN
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1245.28.10033 Boehringer Ingelheim Investigational Site
Blue Ridge, Georgia
880
mi
from 02139
Blue Ridge, GA
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1237.5.01015 Boehringer Ingelheim Investigational Site
Boulder, Colorado
1772
mi
from 02139
Boulder, CO
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502.476.067 Boehringer Ingelheim Investigational Site
Buena Park, California
2581
mi
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Buena Park, CA
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1200.75.54005 Boehringer Ingelheim Investigational Site
Buenos Aires,
5378
mi
from 02139
Buenos Aires,
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1236.1.555 Boehringer Ingelheim Investigational Site
Cadillac, Michigan 49601
729
mi
from 02139
Cadillac, MI
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1218.74.01105 Boehringer Ingelheim Investigational Site
Carrollton, Texas
1544
mi
from 02139
Carrollton, TX
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Boehringer Ingelheim Investigational Site
Cincinnati, Ohio
735
mi
from 02139
Cincinnati, OH
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Boehringer Ingelheim Investigational Site
Columbus, Ohio
640
mi
from 02139
Columbus, OH
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1264.3.01031 Boehringer Ingelheim Investigational Site
Concord, California
2665
mi
from 02139
Concord, CA
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205.452.01189 Boehringer Ingelheim Investigational Site
Corvallis, Oregon
2575
mi
from 02139
Corvallis, OR
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1236.1.534 Boehringer Ingelheim Investigational Site
Cumberland, Rhode Island
32
mi
from 02139
Cumberland, RI
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1268.17.01045 Boehringer Ingelheim Investigational Site
Deland, Florida
1082
mi
from 02139
Deland, FL
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205.452.01038 Boehringer Ingelheim Investigational Site
Encinitas, California
2572
mi
from 02139
Encinitas, CA
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205.452.01323 Boehringer Ingelheim Investigational Site
Erie, Pennsylvania
459
mi
from 02139
Erie, PA
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205.452.01341 Boehringer Ingelheim Investigational Site
Eugene, Oregon
2576
mi
from 02139
Eugene, OR
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1236.1.541 Boehringer Ingelheim Investigational Site
Excelsior Springs, Missouri 64024
1222
mi
from 02139
Excelsior Springs, MO
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1220.48.0043 Boehringer Ingelheim Investigational Site
Falls Church, Virginia
398
mi
from 02139
Falls Church, VA
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1311.3.10103 Boehringer Ingelheim Investigational Site
Farmington, Connecticut
97
mi
from 02139
Farmington, CT
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1301.1.5727 Boehringer Ingelheim Investigational Site
Glendale, Arizona
2295
mi
from 02139
Glendale, AZ
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1236.1.505 Ledeeach Family Medicine
658 Harleysville Pike
Harleysville, Pennsylvania 19438
266
mi
from 02139
Harleysville, PA
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205.452.01269 Boehringer Ingelheim Investigational Site
Haverhill, Massachusetts
28
mi
from 02139
Haverhill, MA
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205.452.01209 Boehringer Ingelheim Investigational Site
Hialeah, Florida
1255
mi
from 02139
Hialeah, FL
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Boehringer Ingelheim Investigational Site
Houston, Texas
1601
mi
from 02139
Houston, TX
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1236.1.546 River Cities Cardiology Research Inst of Middle America
41 Quartermaster Court
Jeffersonville, Indiana 47130
818
mi
from 02139
Jeffersonville, IN
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205.452.01184 Boehringer Ingelheim Investigational Site
Jupiter, Florida
1180
mi
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Jupiter, FL
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1245.25.10156 Boehringer Ingelheim Investigational Site
Kettering, Ohio
704
mi
from 02139
Kettering, OH
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1160.128.1054 Boehringer Ingelheim Investigational Site
Largo, Florida
1194
mi
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Largo, FL
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1218.61.01052 Boehringer Ingelheim Investigational Site
Las Vegas, Nevada
2367
mi
from 02139
Las Vegas, NV
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1199.14.1181 Boehringer Ingelheim Investigational Site
Long Beach, California
2594
mi
from 02139
Long Beach, CA
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Boehringer Ingelheim Investigational Site
Los Angeles, California
2588
mi
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Los Angeles, CA
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1199.14.1186 Boehringer Ingelheim Investigational Site
Madison, Wisconsin
927
mi
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Madison, WI
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1245.28.10020 Boehringer Ingelheim Investigational Site
Medford, Oregon
2601
mi
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Medford, OR
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502.476.106 Boehringer Ingelheim Investigational Site
Menomonee Falls, Wisconsin
863
mi
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Menomonee Falls, WI
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1218.61.01040 Boehringer Ingelheim Investigational Site
Meridian, Idaho
2261
mi
from 02139
Meridian, ID
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1236.1.503 Anchor Research Center
15205 Collier Boulevard
Naples, Florida 34119
1263
mi
from 02139
Naples, FL
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1199.14.1057 Boehringer Ingelheim Investigational Site
New Port Richey, Florida
1172
mi
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New Port Richey, FL
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1245.23.10157 Boehringer Ingelheim Investigational Site
Newton, Kansas
1410
mi
from 02139
Newton, KS
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1222.29.11004 Boehringer Ingelheim Investigational Site
North Dartmouth, Massachusetts
50
mi
from 02139
North Dartmouth, MA
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1218.64.10018 Boehringer Ingelheim Investigational Site
Pembroke Pines, Florida
1244
mi
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Pembroke Pines, FL
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1200.43.00106 Boehringer Ingelheim Investigational Site
Peoria, Illinois
961
mi
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Peoria, IL
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Boehringer Ingelheim Investigational Site
Portland, Oregon
2530
mi
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Portland, OR
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1236.1.566 Boehringer Ingelheim Investigational Site
Richmond, Kentucky
765
mi
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Richmond, KY
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205.452.01001 Boehringer Ingelheim Investigational Site
Salt Lake City, Utah
2091
mi
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Salt Lake City, UT
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Boehringer Ingelheim Investigational Site
San Antonio, Texas
1763
mi
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San Antonio, TX
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502.476.097 Boehringer Ingelheim Investigational Site
Sandy, Utah
?
mi
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Sandy, UT
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Boehringer Ingelheim Investigational Site
Spartanburg, South Carolina
776
mi
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Spartanburg, SC
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9.197.001 Boehringer Ingelheim Investigational Site
Tempe, Arizona
2286
mi
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Tempe, AZ
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1236.1.570 Boehringer Ingelheim Investigational Site
The Colony, Texas
1540
mi
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The Colony, TX
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1245.25.10162 Boehringer Ingelheim Investigational Site
Tipton, Pennsylvania
390
mi
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Tipton, PA
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1236.1.525 Physicians Research Center, LLC, Toms River
9 Mule Road
Toms River, New Jersey 08755
232
mi
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Toms River, NJ
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205.452.01221 Boehringer Ingelheim Investigational Site
Troy, Michigan
613
mi
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Troy, MI
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1268.17.01043 Boehringer Ingelheim Investigational Site
Tucson, Arizona
2277
mi
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Tucson, AZ
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205.452.01307 Boehringer Ingelheim Investigational Site
Tulsa, Oklahoma
1393
mi
from 02139
Tulsa, OK
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205.452.01362 Boehringer Ingelheim Investigational Site
Tustin, California
2576
mi
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Tustin, CA
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1245.25.10206 Boehringer Ingelheim Investigational Site
Valparaiso, Indiana
821
mi
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Valparaiso, IN
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1236.1.561 Clinical Research Center of Cape Cod
131 Attucks Lane
West Yarmouth, Massachusetts 02601
62
mi
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West Yarmouth, MA
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1218.74.01069 Boehringer Ingelheim Investigational Site
Westlake Village, California
2614
mi
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Westlake Village, CA
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1199.14.1097 Boehringer Ingelheim Investigational Site
Wichita, Kansas
1418
mi
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Wichita, KS
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