Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures

The inclusion criteria are:

1. Patients 18 years of age or older.

2. Open fracture of the appendicular skeleton.

3. Received or will receive definitive fracture treatment with a surgical implant(s)
(e.g., internal fixation, external fixation, joint prosthesis, etc.).

4. Open fracture wound management that includes formal surgical debridement within 72
hours of their injury.

5. Will have all planned fracture care surgeries performed by a participating surgeon or
delegate.

6. Informed consent obtained.

7. Patient enrolled within 3 weeks of their fracture.

The exclusion criteria are:

1. Patients that did not or will not receive the allocated pre-operative surgical
preparation solution due to a medical contraindication.

2. Received previous surgical debridement or management of their open fracture at a
non-participating hospital or clinic.

3. Open fracture managed outside of the participating orthopaedic service (e.g., hand
fracture managed by plastic surgeon).

4. Chronic or acute infection at or near the fracture site at the time of initial
fracture surgery.

5. Burns at the fracture site.

6. Incarceration.

7. Expected injury survival of less than 90 days.

8. Terminal illness with expected survival less than 90 days.

9. Currently enrolled in a study that does not permit co-enrollment.

10. Unable to obtain informed consent due to language barriers.

11. Problems, in the judgment of study personnel, with maintaining follow-up with the
patient.

12. Previously enrolled in the Aqueous-PREP trial.