Evaluation of Plant-based Nutritional Products on Stem Cells

The purpose of this clinical study is to evaluate acute effects of plant-based nutritional
extracts on adult stem cells, using a randomized double-blinded placebo-controlled cross-over
study design. The research involves testing of acute effects of single doses of
antioxidant-rich berry-based extracts, compared to a placebo. Blood samples are taken at
baseline and 1 and 2 hours after consuming a single dose. The blood will be used to measure
the numbers of different types of stem cells, to evaluate potential effects of stem cell
mobilization and homing after consuming plant-based extracts. Adult stem cells are a type of
cells that play a role in repairing and rejuvenating various tissue and organs in the body.
At NIS Labs, we have shown that many types of plant-based nutritional products have small but
reproducible and significant effects on stem cells, cytokines, and regenerative growth
factors.

Inclusion Criteria:

- Healthy adults 20-75 years of age;

- Body weight higher than 110 pounds;

- BMI below 35;

Exclusion Criteria:

- Previous major gastrointestinal surgery (absorption of test product may be altered)
(minor surgery not a problem);

- Currently taking daily OTC medications, such as NSAIDs, Tylenol, allergy medications,
and others (birth control and 81 mg aspirin not a problem);

- Taking medications that affect the mind (such as anti-depressants) or nervous system
(such as gabapentin);

- Currently experiencing intense stressful events and life changes;

- Actively depressed;

- Experiencing sleep disturbances;

- Working night shift;

- Pregnant, nursing, or trying to become pregnant;

- Food intolerances or allergies currently causing discomfort (such as Celiac's
disease), due to ongoing inflammatory reactions that may negatively affect product
absorption within the 3 hours of testing;

- Food allergies related to ingredients in test product.