Ridge Preservation Comparing the Healing With or Without a Barrier Membrane

Thirty patients will be treated using the principles of bone grafting for ridge preservation.
Fifteen test patients will receive a flap technique with an intrasocket cancellous cortical
particulate allograft plus a facial overlay graft using a bovine xenograft without a membrane
where only the exposed intrasocket allograft will be covered with a piece of Alloderm GBR.
The positive control group of fifteen patients will receive a flap technique with an
intrasocket cancellous cortical particulate allograft plus a facial overlay graft using a
bovine xenograft plus Alloderm GBR membrane. Approximately, four months post-surgery, a
trephine core will be taken from the grafted site immediately prior to implant placement and
submitted for histologic processing.

Inclusion Criteria:

1. Have one non-molar tooth requiring extraction that will be replaced by a dental
implant. The site must be bordered by at least one tooth.

2. Healthy male or female who is at least 18 years old.

3. Patients must sign an informed consent approved by the University of Louisville Human
Studies Committee.

Exclusion Criteria:

1. Patients with debilitating systemic diseases, or diseases that have a clinically
significant effect on the periodontium.

2. Presence or history of osteonecrosis of jaws.

3. Patients who are currently taking IV bisphosphonates or who had IV treatment with
bisphosphonates irrespective of duration.

4. Patients who have been treated with oral bisphosphonates for more than three years.

5. Patients with an allergy to any material or medication used in the study.

6. Patients who need prophylactic antibiotics

7. Previous head and neck radiation therapy.

8. Chemotherapy in the previous 12 months.

9. Patients on long term NSAID or steroid therapy.

10. Pregnant patients.