Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury
| Status: | Recruiting |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 10/19/2018 |
| Start Date: | September 9, 2018 |
| End Date: | February 2020 |
| Contact: | Hien Pham |
| Email: | hien.pham@nyumc.org |
| Phone: | 646 501 7223 |
Can Platelet Rich Plasma Reduce the Level of Pro-Inflammatory Synovial Fluid Biomarkers Following an Anterior Cruciate Ligament Tear
The purpose of this single-center, double-blinded randomized control trial with prospective
data collection is to assess the ability of platelet rich plasma (PRP) treatment to reduce
the level of pro-inflammatory synovial fluid biomarkers following an acute anterior cruciate
ligament (ACL) tear. The study will collect and analyze synovial fluid of patients presenting
with an acute anterior cruciate ligament (ACL) tear with a second synovial fluid sampling at
the time of surgery. It will compare synovial fluid biomarker levels between those receiving
an intra-articular Platelet Rich Plasma (PRP) injection versus an intra-articular saline
injection serving as a control. Post-operative clinical outcomes will also be assessed,
including post-operative pain levels, incidence of post-operative knee stiffness and patient
reported outcome scores.
data collection is to assess the ability of platelet rich plasma (PRP) treatment to reduce
the level of pro-inflammatory synovial fluid biomarkers following an acute anterior cruciate
ligament (ACL) tear. The study will collect and analyze synovial fluid of patients presenting
with an acute anterior cruciate ligament (ACL) tear with a second synovial fluid sampling at
the time of surgery. It will compare synovial fluid biomarker levels between those receiving
an intra-articular Platelet Rich Plasma (PRP) injection versus an intra-articular saline
injection serving as a control. Post-operative clinical outcomes will also be assessed,
including post-operative pain levels, incidence of post-operative knee stiffness and patient
reported outcome scores.
Inclusion Criteria:
- Patients have suffered an acute ACL tear (initial presentation within 7 days of
injury) with or without an associated meniscus injury
- Patient must undergo ACL reconstruction surgery
Exclusion Criteria:
- Mentally impaired (e.g, Alzheimer's subjects, dementia, etc.)
- Younger than 18 years of age
- Patients who have a multiligamentous injury
- Patients with underlying inflammatory arthropathies
- Previous ACL injury and/or reconstruction
We found this trial at
1
site
550 1st Ave
New York, New York 10016
New York, New York 10016
(212) 263-7300
Principal Investigator: Eric Strauss, MD
Phone: 646-501-7223
New York University School of Medicine NYU School of Medicine has a proud history that...
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