Diagnosing Respiratory Disease in Children Using Cough Sounds 2

Inclusion Criteria:

- Infant or child aged greater than 29 days up to and including their 12th birthday
(infant and children pediatric subgroups as defined in Guidance for Industry and Food
and Drug Administration Staff: Premarket Assessment of Pediatric Medical Devices dated
March 24, 2014)

- Presenting to the study site (an outpatient facility, an urgent care center, an
Emergency Department, or inpatient ward within 24 hours of admission) with current
signs or symptoms of respiratory disease including cough, wheezing, stridor, chest
in-drawing/retractions, difficulty breathing, fast breathing, nasal
congestion/rhinorrhea, abnormal lung sounds on exam or cyanosis/hypoxemia.

- Onset of symptoms within past 14 days

- Outpatient or inpatient within 24 hours of admission

- Coughing spontaneously or able to cough voluntarily

Exclusion Criteria:

- Lack of a signed consent form from parent or legal guardian

- Lack of signed assent form for children aged 7 years or older who, in the opinion of
the investigator, is able to provide assent based on their age, maturity or
psychological state.

- Need for mechanical ventilatory support ((including invasive, CPAP, or BiPAP)) or high
flow nasal cannula

- History of structural airways abnormalities, tracheobronchomalacia, or vocal cord
abnormalities (e.g. laryngomalacia, tracheomalacia, or bronchomalacia)

- Any medical contraindication to voluntary cough, including the following (only enroll
if coughing spontaneously): severe respiratory distress, history of pneumothorax,
eye/chest/abdominal surgery in past 3 months, hemoptysis in the past month

- Too medically unstable to participate in study per treating clinician

- Subject previously enrolled in SMARTCOUGH-C-2 study

- Tracheostomy present or tube placed