Nerve Burial for Preventing Neuralgia After Total Knee Arthroplasty



Status:Terminated
Conditions:Arthritis, Osteoarthritis (OA), Neurology
Therapuetic Areas:Neurology, Rheumatology
Healthy:No
Age Range:18 - 80
Updated:5/23/2018
Start Date:August 2013
End Date:May 2018

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Saphenous Nerve Brach Burial for Preventing Neuralgia After Total Knee Arthroplasty: A Randomized Controlled Trial

This is a randomized study investigating whether identification, ligation, and burial of
superficial branches of the saphenous nerve crossing the surgical field during total knee
arthroplasty reduces the rate of post-operative anterior knee pain and neuralgia compared to
standard total knee arthroplasty.

Anterior knee pain is common after total knee arthroplasty. The incision necessarily travels
through the path of a cutaneous nerve - branches of the saphenous nerve. Historically, no
effort has been made to separate these branches and bury them away from the surgical scar. It
has been noted that some patients develop a painful neuroma, that once resected results in a
pain free knee. Investigators are trying to study if identification, ligation, and proper
burial of the nerve can prevent the development of neuralgia compared to the typical surgical
approach which ignores the nerve branches completely.

Inclusion Criteria:

- Must have symptomatic knee osteoarthritis under consideration for total knee
arthroplasty

- Must be willing to undergo randomization

Exclusion Criteria:

- Age <18 or >80 years

- Known pre-operative diagnosis of neuralgia, complex regional pain syndrome, or
neuropathy, about the operative lower extremity

- Known pre-operative psychiatric disorder requiring medication

- Previous surgery about the operative knee

- BMI > 40 kg/m2 (potential increased risk of soft tissue dissection through adipose)

- Ongoing pre-operative narcotic use in excess of 20 mg morphine equivalents per day for
at least one month or pre-operative intravenous drug use (increased potential for
complex regional pain syndrome and neuralgia, increased likelihood to require greater
post-operative analgesia)

- Ongoing pre-operative use of neuropathic pain medications (gabapentin, pregabalin,
amitriptyline, etc.)

- Medical comorbidities (American Society of Anesthesiologists grade > 3 or deemed unfit
by consulting internist) precluding elective TKA

- Significant language barrier (reading comprehension less than 8th grade reading level)
or mental condition precluding accurate self-assessment of knee pain or function.

- Severe medication allergies to permissible post-operative analgesics (acetaminophen,
tramadol, oxycodone, oxycontin, dilaudid)
We found this trial at
1
site
Baltimore, Maryland 21218
Phone: 410-554-2000
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Baltimore, MD
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