The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition

Niagen is a patented formula which is the first and only commercially available form of
Nicotinamide Riboside (NR). It has been proven in basic science studies as a highly effective
NAD booster, but it also works as a vitamin B3 supplement. NAD helps pass energy from glucose
to other pathways in the cell. Niagen (Nicotinamide Riboside, vitamin B3) is one of the most
effective NAD+ precursors to support cellular health.

The purpose of this study is to determine the effects of Niagen (nicotinamide riboside,
vitamin B3), on NAD levels, brain function including cognition and blood flow in people
diagnosed with mild cognitive impairment (MCI).

Inclusion Criteria:

- Previously diagnosed with MCI based on inclusion criteria of Texas Alzheimer's
Research Care and Consortium (TARCC) study (IRB: HSC20090535H). We are enrolling both
genders, all races and ethnic groups.

Exclusion Criteria:

- Previously considered as healthy individuals without a MCI or Alzheimer's disease
diagnosis based on exclusion criteria of the TARCC study (IRB: HSC20090535H).

- Neurological, psychiatric or active systemic medical disease

- Diabetes

- Moderate or severe depression and/or anxiety as determined the Geriatric Depression
Scale (GDS) and the Geriatric Anxiety Scale (GAS), respectively

- Diagnosis of dementia

- Hearing, vision, motor or language deficits

- Alcohol or drug abuse

- Implantation of metal devices

- Administration of Alzheimer's drugs, anticholinergics, neuroleptics, anticonvulsants,
opiates, systemic steroids, and mood-stabilizers.