Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Hospital |
| Therapuetic Areas: | Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | March 5, 2018 |
| End Date: | August 30, 2020 |
| Contact: | Gretchen Bernardini, RN |
| Email: | Gretchen.Bernardini@chp.edu |
| Phone: | 412-647-2931 |
Biochemical and Reno-protective Effects of Remote Ischemic Pre-conditioning on Contrast-induced Acute Kidney Injury
This a prospective, double-blind, sham-controlled, randomized clinical trial to study the
effects of remote ischemic preconditioning on contrast-induced acute kidney injury, vascular
and renal biomarkers in patients with non-ST elevation myocardial infarction and unstable
angina undergoing cardiac catheterization and percutaneous coronary intervention.
effects of remote ischemic preconditioning on contrast-induced acute kidney injury, vascular
and renal biomarkers in patients with non-ST elevation myocardial infarction and unstable
angina undergoing cardiac catheterization and percutaneous coronary intervention.
The BRICK study is a prospective, double-blind, sham-controlled, randomized clinical trial in
patients with non-ST elevation myocardial infarction and unstable angina undergoing cardiac
catheterization and percutaneous coronary intervention who are at high risk for
contrast-induced acute kidney injury. The study will investigate the effects of remote
ischemic preconditioning before cardiac catheterization on rate of contrast induced acute
kidney injury and novel biomarkers of renal injury/protection within 48hrs of cardiac
catheterization.
patients with non-ST elevation myocardial infarction and unstable angina undergoing cardiac
catheterization and percutaneous coronary intervention who are at high risk for
contrast-induced acute kidney injury. The study will investigate the effects of remote
ischemic preconditioning before cardiac catheterization on rate of contrast induced acute
kidney injury and novel biomarkers of renal injury/protection within 48hrs of cardiac
catheterization.
Inclusion Criteria:
- Patient with non-ST elevation myocardial infarction or unstable angina
- Referral for cardiac catheterization and percutaneous coronary intervention
- Contrast-induced acute kidney injury risk score of ≥11
Exclusion Criteria:
- Inability to give informed consent
- unstable blood pressure (systolic blood pressure > 200 or <90 mmHg)
- History of allergy to contrast media
- Peripheral vascular disease of upper limb
- Renal disease requiring dialysis
- Placement of arteriovenous fistula and arteriovenous graft
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