Accelerated rTMS for the Reduction of Nicotine Craving



Status:Terminated
Conditions:Smoking Cessation, Smoking Cessation, Tobacco Consumers
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 70
Updated:3/27/2019
Start Date:January 1, 2018
End Date:December 12, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

Accelerated Repetitive Transcranial Magnetic Stimulation (rTMS) of the Dorsolateral Prefrontal Cortex for the Reduction of Craving in Nicotine Dependent Individuals

The purpose if this study is to determine if five treatments of repetitive transcranial
magnetic stimulation (rTMS) can reduce craving for cigarettes in smokers. rTMS uses magnetic
pulses to stimulate the brain and is currently approved for the treatment of major depressive
disorder.


Inclusion Criteria:

- Outpatient Adults aged 18-70

- Cigarette Smokers smoking at least 1 pack (20 cigarettes a day) with current smoking
status confirmed by exhaled CO reading of >10ppm day of visit.

- Ability to provide informed consent

Exclusion Criteria

- Current treatment with varenicline or bupropion

- Currently making a smoking quit attempt (not currently smoking).

- Current treatment with an antidepressant, anti-convulsant, anxiolytic, antipsychotic
or mood stabilizer.

- Current episode of major depression determined by MINI interview.

- Current or past history of schizophrenia, schizoaffective disorder, anorexia nervosa,
bulimia or bipolar disorder as determined by MINI.

- Current daily consumption of alcohol or current alcohol use disorder.

- Current substance use disorder except for nicotine or cannabis use disorder.

- Currently pregnant or lactating.

- Contraindications to rTMS including history of seizure, metal implanted above the
neck, pacemaker or any brain lesion.

- Unstable medical conditions

- Suicidal ideation or history of suicide attempt within the last six months.

- Inability or unwillingness of subject or legal guardian/representative to give
informed consent
We found this trial at
1
site
MUSC Institute of Psychiatry
67 President Street
Charleston, South Carolina 29425
Principal Investigator: David Friedrich, MD
Phone: 843-792-2300
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mi
from
Charleston, SC
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