Early Molecular Changes in Vitiligo After Narrowband Ultraviolet Therapy

This is a dermatology study of the effects of short-term NB-UVB treatment, standard
phototherapy for Vitiligo patients. In the study, demographics information, three ascending
dose of phototherapy, and small skin biopsies will be required of the participants.

For all enrolled participants, the starting dose of NB-UVB administered will be 250 mJ/cm2,
which is the standard of care for patients with Vitiligo. The dose will be increased by 10%
with each treatment, as long as there are no side effects with treatment such as burning or
redness/ erythema. Small skin biopsies will be collected from normal skin and from affected
skin from vitiligo participants at the baseline visit and 3 days after the conclusion of
treatment; up to a total of 6 biopsies will be collected from each patient. Participants will
be compensated for time and effort.

Inclusion Criteria:

- Adults 18 years or older with bilateral symmetrical vitiligo lesions, in general good
health as determined by the Principal Investigator by medical history and physical
exam.

- Able to understand consent procedure

- Able to comply with protocol activities

Exclusion Criteria:

- Patients less than 18 years old

- Patients not able to understand consent procedure

- Patients unable to comply with protocol activities

- Non-English speakers: the study assessments/questionnaires/evaluations are not
scientifically validated in languages other than English.

- Patients with a photosensitive disorder or on a medication which has been demonstrated
in these patients to cause photosensitivity

- Patients receiving concomitant phototherapy to test sites

- Patient receiving topical medication to test sites within 2 weeks of study initiation

- Patient receiving oral medications for vitiligo within 4 weeks prior to study
initiation

- Receipt of an investigation agent within the past 4 weeks (or within 5 half lives)
prior to study initiation

- Pregnant or nursing patients (self-reported)

- Patient with significant medical history or concurrent illness that the investigator
feels is not safe for study participation, including melanoma

- Presence or suspicion of bleeding disorder or diathesis which would complicate biopsy.

- Patients with history of excessive scar or keloid formation in the past 10 years

- Patients with known allergy to anesthetic used

- Subjects with a pacemaker, implanted cardioverter-defibrillator, baroreflex activation
device, cochlear implant, implanted bone growth stimulator, robotic limb prosthesis,
subcutaneous GPS tracking device, electrodes implanted in the brain, attached
electrodes in a subject undergoing cardiac defibrillation during the moment of skin
color reading, or other device which may be disrupted by electrical current, UNLESS
subject is kept "1 yard (one arm's length) from the main unit" of the
spectrophotometer at all times, as specified in device approval letter.