A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Open Angle Glaucoma

The purpose of this study is to evaluate the safety and efficacy of the iStent trabecular
micro-bypass stent in reducing intraocular pressure (IOP) in subjects with open-angle
glaucoma or ocular hypertension and co-existing cataract. Pre-operative unmedicated baseline
pressures will be compared with post operative values in both study arms.

Inclusion Criteria:

- Diagnosed with open-angle glaucoma (OAG) in the study eye. Pseudoexfoliative and
pigmentary glaucoma are also acceptable diagnoses.

- Subject on at least one glaucoma medication

- Able and willing to attend follow up visits for two years post operative

- Able and willing to sign informed consent

Exclusion Criteria:

- Prior glaucoma procedures (eg trabeculectomy, viscocanalostomy, ALT, SLT, shunt
implant, collagen implant, cyclo destructive procedures etc)

- Angle closure glaucoma

- Fellow eye already enrolled