Oracea Soolantra Association in Patients With Severe Rosacea

Inclusion Criteria:

- Male or female subject age ≥ 18 years or older;

- Subject with a minimum of 20 but not more than 70 inflammatory lesions (papules and
pustules) of rosacea on the face at Baseline visit;

- Subject with severe rosacea with papulopustular lesions (according to the
Investigator's Global Assessment, IGA score rated 4);

- Female subjects of childbearing potential with a negative urine pregnancy test (UPT);

- Female subjects of childbearing potential must practice a highly effective method of
contraception during the study;

Exclusion Criteria:

- Subjects with particular forms of rosacea or other concomitant facial dermatoses that
may be confounded with rosacea;

- Subjects with more than 2 nodules of rosacea on the face;

- Subjects with any uncontrolled chronic or serious disease or medical condition that
may either interfere with the interpretation of the clinical trial results, or with
optimal participation in the study or would present a significant risk to the subject;

- Subjects with known or suspected allergies or sensitivities to any component of the
investigational and non-investigational products, including the active ingredients
doxycycline and ivermectin;