SEEG Investigation of Mood Dysregulation in Epilepsy
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Neurology, Epilepsy |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 3/2/2019 |
| Start Date: | February 27, 2017 |
| End Date: | July 2020 |
SEEG Investigation of Mood Dysregulation in People With Epilepsy
Using the novel analysis of stereo-electroencephalography (SEEG) recordings, this proposal
will investigate the activity and connectivity of mood regulation circuits in subjects with
suspected epileptic focus who have undergone SEEG electrode implantation for monitoring of
seizure activity.
will investigate the activity and connectivity of mood regulation circuits in subjects with
suspected epileptic focus who have undergone SEEG electrode implantation for monitoring of
seizure activity.
It is well known that epilepsy is associated with mood dysregulation including symptoms of
labile mood, impulse control problems, anxiety, depression and increase in incidence of
suicide. However, until present the neurobiological basis of mood dysregulation in epilepsy
has not been clear and has been mostly attributed to a psychological reaction to the illness.
This has severely limited our understanding of the impairments in mood regulation that people
with epilepsy often experience and has also limited the development of effective treatment
for ameliorating psychosocial dysfunction in people with epilepsy. The identification of
these circuits will not only increase our understanding of mood-regulation in epilepsy but
also possibly provide biomarkers with which the effectiveness of new treatments can be
investigated. Developing better diagnostic measures and treatments for mood dysregulation
will be highly beneficial to the quality of life of subjects suffering from epilepsy.
labile mood, impulse control problems, anxiety, depression and increase in incidence of
suicide. However, until present the neurobiological basis of mood dysregulation in epilepsy
has not been clear and has been mostly attributed to a psychological reaction to the illness.
This has severely limited our understanding of the impairments in mood regulation that people
with epilepsy often experience and has also limited the development of effective treatment
for ameliorating psychosocial dysfunction in people with epilepsy. The identification of
these circuits will not only increase our understanding of mood-regulation in epilepsy but
also possibly provide biomarkers with which the effectiveness of new treatments can be
investigated. Developing better diagnostic measures and treatments for mood dysregulation
will be highly beneficial to the quality of life of subjects suffering from epilepsy.
Inclusion Criteria:
- Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings
and analysis
Exclusion Criteria:
- Subjects that experience surgical complications during the implant procedure will be
excluded from the study
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