Twice Daily Versus Twice Weekly Soak-and-Seal Baths in Pediatric Atopic Dermatitis
| Status: | Completed |
|---|---|
| Conditions: | Psoriasis, Dermatology, Dermatology, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | Any - 11 |
| Updated: | 1/14/2018 |
| Start Date: | November 14, 2011 |
| End Date: | March 21, 2017 |
Twice Daily Versus Twice Weekly Soak-and-Seal Baths in Pediatric Atopic Dermatitis: A Randomized, Single-blinded, Prospective Crossover Controlled Trial
There are few studies evaluating best bathing practices in the management of pediatric atopic
dermatitis (AD). Trans-epidermal water loss plays a key role in the pathophysiology of AD. In
concert with application of topical corticosteroids (TCS), we sought to investigate whether
frequent soaking baths (i.e. twice daily for two weeks), followed immediately by application
of an occlusive moisturizer (i.e. soak-and-seal), would be more effective than infrequent
soaking baths (i.e. twice weekly for two weeks) in the management of AD.
dermatitis (AD). Trans-epidermal water loss plays a key role in the pathophysiology of AD. In
concert with application of topical corticosteroids (TCS), we sought to investigate whether
frequent soaking baths (i.e. twice daily for two weeks), followed immediately by application
of an occlusive moisturizer (i.e. soak-and-seal), would be more effective than infrequent
soaking baths (i.e. twice weekly for two weeks) in the management of AD.
To evaluate the effectiveness of twice daily soak-and-seal baths for improving severity of
disease in children with AD, we implemented a randomized clinical trial using a single-blind,
crossover-controlled design. Patients received the same moisturizer, cleanser, and class VI
topical corticosteroid (TCS), and only bathing varied. After a 1 week run-in, children were
randomized 1:1 into 2 groups: Group 1 underwent twice weekly soak-and-seal baths for 2 weeks
("dry method") followed by twice daily soak-and-seal baths for 2 weeks ("wet method"), and
group 2 did the converse. A single treating physician assessed outcomes and, along with those
analyzing the data, was masked to group assignment. Participants and their caregivers could
not be masked. Analyses were based on intention to treat.
disease in children with AD, we implemented a randomized clinical trial using a single-blind,
crossover-controlled design. Patients received the same moisturizer, cleanser, and class VI
topical corticosteroid (TCS), and only bathing varied. After a 1 week run-in, children were
randomized 1:1 into 2 groups: Group 1 underwent twice weekly soak-and-seal baths for 2 weeks
("dry method") followed by twice daily soak-and-seal baths for 2 weeks ("wet method"), and
group 2 did the converse. A single treating physician assessed outcomes and, along with those
analyzing the data, was masked to group assignment. Participants and their caregivers could
not be masked. Analyses were based on intention to treat.
Inclusion Criteria:
- Infants and children ages 6 months to 11 years of age with moderate to severe atopic
dermatitis according to the criteria of Hanifin and Rajka.
Exclusion Criteria:
- Patients with suspected or established primary immune deficiency, patients receiving
systemic corticosteroids, ultraviolet light therapy, immuno-therapeutic agents, and/or
anti-infective drugs less than 1 month from the onset of the study.
We found this trial at
1
site
Click here to add this to my saved trials
