Evaluation of the Effects of Cannabidiol (CBD) Compared to Delta-9-Tetrahydrocannabinol (THC) and Alprazolam

This is a single-dose, randomized, double-blind, placebo- and active-controlled crossover
study that evaluates CBD in comparison with THC, alprazolam, and placebo in healthy
recreational drug users.

Inclusion Criteria:

- Must understand and provide written informed consent prior to the initiation of any
protocol-specific procedures.

- Male or female subjects 18 to 55 years of age, inclusive.

- Body mass index (BMI) within the range of 19.0 to 30.0 kg/m2, inclusive, and a minimum
weight of at least 50.0 kg.

- Healthy, as determined by no clinically significant medical history, physical
examination,

- 12-lead ECG, vital signs or laboratory (including hematology, clinical chemistry
biochemistry, urinalysis, and serology) findings at Screening, as judged by the
investigator.

- Must be a recreational drug user, defined as meeting all of the following criteria:

- ≥10 lifetime non-therapeutic experiences (i.e., for psychoactive effects) with
CNS depressants (e.g., benzodiazepines, barbiturates, zolpidem, eszopiclone,
propofol/fospropofol, gamma-hydroxy-butyrate).

- ≥10 lifetime non-therapeutic experiences with cannabinoids (e.g., cannabis,
hashish, THC, nabilone).

- At least 3 non-therapeutic uses of a sedative, and at least 3 non-therapeutic
uses of a cannabinoid, within the 3 months prior to Screening.

- Must pass Qualification Phase eligibility criteria.

- Female subjects of childbearing potential who are not abstinent must be using and
willing to continue using medically acceptable contraception throughout the trial and
for 30 days after last dose. In the context of this trial, highly effective methods of
contraception are defined as those, alone or in combination, that result in a low
failure rate (i.e., less than 1% per year) when used consistently and correctly. Such
methods include hormonal contraceptives, intrauterine devices/hormone-releasing
systems, double-barrier methods, bilateral tubal occlusion, vasectomized partner, or
sexual abstinence. Abstinence is only acceptable as true (total) abstinence, when this
is in line with the preferred and usual lifestyle of the patient; periodic abstinence
(e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are
not acceptable methods of contraception.

- Non-vasectomized male subjects must agree to a highly effective method of
contraception with female partner(s) of childbearing potential and may not donate
sperm throughout the trial and for 90 days after the last study drug administration.

- Able to speak, read, and understand English sufficiently to allow completion of all
study assessments.

- Must be willing and able to abide by all study requirements and restrictions.

Exclusion Criteria:

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