Targeting Stress-Induced Alcohol Relapse Risk With Doxazosin XL

Inclusion Criteria:

- Meet DSM-5 criteria for AUD;

- Report excessive alcohol use as defined by CDC guidelines in the past month (>7
drinks/week for woman, >14 drinks/week for men, >3 drinks/occasion for women>4
drinks/occasion for men)3.

Exclusion Criteria:

- Physical dependence on alcohol assessed using the SCID and Clinical Institute
Withdrawal Assessment for Alcohol (CIWAA)41.

- Presenting an Alcohol Use Disorders Inventory (AUDIT) score indicative of severe
alcohol dependence (≥13 for women, ≥15 for men);

- Meeting criteria for substance use disorder on drugs other than alcohol and nicotine;

- Currently taking a prescribed psychoactive medication (e.g., atomoxetine for ADHD). In
addition, exclusion for those individuals taking CYP3A4 inhibitors. Most participants
will not be taking any concomitant medications (including over-the-counter
supplements). For those who are taking an allowed medication, the study physician will
determine if the medications are CYP3A4 inhibitors.

- Medical conditions contraindicating doxazosin XL pharmacotherapy (e.g., postural
hypotension);

- Taking contraindicated medications such as blood pressure medications;

- Be pregnant, nursing, or planning on becoming pregnant during the course of the study;

- Have any other illness, condition, or use of medications, which in the opinion of the
PI and/or admitting physician would preclude safe and/or successful completion of the
study.