Vascular Risk Progression in Normal and Diabetic Control Subjects.

Cardiovascular disease remains the greatest cause of mortality in people with diabetes
mellitus. This observation study will evaluate non-traditional risk factors for their
contributions to vascular disease progression as determined by carotid intima media thickness
and history of vascular disease events over 1 year. This study requires annual checks of
blood, urine, history, and carotid ultrasound for carotid intimal medical thickness.

Inclusion Criteria:

- 19 years old or more and willing to return for annual testing for 2 years.

- Those with Diabetes need to have the condition for at least 5 years.

- Normal controls need to have no diabetes, kidney disease, or chronic disease.

Exclusion Criteria:

- Estimated GFR <60 (mL/min/1.73m2)

- Any condition that would change weight dramatically in the near future such as
malabsorption, pregnancy, malignancy

- For Normal: BMI>30, BP > 140/90 , LDL > 130.

- For Diabetes: BP> 135/85, A1C> 8%. LDL > 100.