Technical Development for Pediatric Cardiovascular MRI

The purpose of this protocol is to allow development and testing of new MRI techniques
suitable for evaluating patients with cardiovascular disease, congenital heart disease, fetal
cardiac structure, function, and physiology, and other fetal organ analysis. Individuals
referred to Children's National Medical Center for a clinically indicated cardiac MRI or
cardiac catheterization by their primary referring cardiologist or obstetrician, and who are
enrolled in this study may also undergo additional research imaging.

Since such technical development work often depends on preliminary studies in healthy
volunteers, the protocol also recruits healthy subjects.

Inclusion Criteria:

Clinically indicated exams

1. Patients who are undergoing a medically indicated MRI scan or cardiac catheterization
procedure

2. Patients who are medically judged to have no contraindications to MRI scan

3. Age inclusion: infant to adult

4. Written informed consent and assent, when applicable

Volunteers

1. Written informed consent from any normal volunteer 8 years of age or older for a
noncontrast, nonsedated cardiac MRI

2. Normal adult volunteer to undergo cardiac MRI with contrast agent

Fetal exams

1. Age inclusion:18 years and older

2. Second or third trimester (greater than 13 weeks)

Exclusion Criteria:

1. All patients who are medically judged to have contraindication(s) to MRI scanning will
be excluded. Contraindications include implanted metal devices which are
contraindicated for MRI scanning:

- Central nervous system aneurysm clips;

- Implanted neural stimulator;

- Implanted cardiac pacemaker or defibrillator;

- Cochlear implant;

- Ocular foreign body (e.g. metal shavings);

- Implanted Insulin pump;

- Metal shrapnel or bullet.

2. Exclusion criteria for Bicycle Stress MRI

- Myocardial infarction within 24 hours

- Active myocarditis

- Uncontrolled heart failure

- Severe left ventricular outflow tract obstruction

3. Exclusion Criteria for adult volunteers undergoing MRI with administration of contrast
agent:

- 60 years of age or older

- Renal Disease; Glomerular Filtration rate (eGFR < 30 ml/min/1.73 m2) will be
determined by a simple blood test done at the bedside

- Use of diuretics

- Diagnosis of hypertension and diabetes

4. Exclusion criteria for volunteers undergoing both contrast and non-contrast

MRI scans:

- Pregnant women:

1. Women of childbearing potential will be required to have a screening urine
pregnancy test

5. Exclusion criteria for

- Pregnant woman for whom 15 additional minutes lying flat in the MR scanner would
represent a risk (i.e. severe claustrophobia, congestive heart failure)

- Pregnant minor under the age of 18

- Less than 13 weeks gestation