Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 30 - 75 |
| Updated: | 3/24/2019 |
| Start Date: | January 25, 2017 |
| End Date: | December 2019 |
| Contact: | Kristina Petersen, PhD |
| Email: | kup63@psu.edu |
| Phone: | 814-863-8622 |
The Effect of Chronic Consumption of Popular Spices on Risk Factors for Cardiovascular Disease (CVD), Inflammation & Immune Function, and Diet Satisfaction
This study is a randomized 3-period crossover, controlled feeding study designed to evaluate
the effects of the most commonly consumed spices in the U.S. on CVD risk factors,
inflammation & immune function, and diet satisfaction in participants at risk for CVD.
the effects of the most commonly consumed spices in the U.S. on CVD risk factors,
inflammation & immune function, and diet satisfaction in participants at risk for CVD.
A 3-period randomized crossover controlled-feeding study will be conducted. Participants will
be randomly assigned to receive each 4-week treatment (diet) in random order. Each test diet
period will be separated by a standard 4-week compliance break. Data collection will be
conducted across at baseline (start of study) and the end of each diet period to assess the
effects of chronic spice consumption on selected cardiovascular endpoints.
be randomly assigned to receive each 4-week treatment (diet) in random order. Each test diet
period will be separated by a standard 4-week compliance break. Data collection will be
conducted across at baseline (start of study) and the end of each diet period to assess the
effects of chronic spice consumption on selected cardiovascular endpoints.
Inclusion Criteria:
- overweight or obese (25-35kg/m2)
- non-smoking
- male or female
- waist circumference >= 94cm for men and >=80cm for women
- at least one other of the following: LDL- cholesterol >130mg/dL; CRP >1mg/L;
triglycerides >=150mg/dL; HDL <40mg/dL for men or <50mg/dL for women; systolic blood
pressure >= 130mmHg or diastolic >= 85mmHg; fasting glucose >=100mg/dL
Exclusion Criteria:
- diabetes (fasting glucose >126mg/dL)
- hypertension (systolic blood pressure >160mmHg or diastolic blood pressure >100mmHg)
- prescribed anti-hypertensive or glucose lowering drugs
- established cardiovascular disease, stroke, diabetes, liver, kidney or autoimmune
disease
- use of cholesterol/lipid lowering medication or supplementation (psyllium, fish oil,
soy lecithin, phytoestrogens) and botanicals
- pregnancy or lactation
- weight loss of >=10% of body weight within the 6 months prior to enrolling in the
study
- vegetarianism
We found this trial at
1
site
University Park, Pennsylvania 16802
Principal Investigator: Penny Kris-Etherton, PhD
Phone: 814-863-8622
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