Physiopathologic Aspects and Quality of Life in Participants With Eye Dark Circles

Inclusion Criteria:

- Participants with Fitzpatrick skin type I-VI

- Willingness to not wear any eye makeup on the day of the study visit prior to the
study visit appointment

- Willingness to cleanse the face and remove all makeup at least 15 minutes prior to
each scheduled clinic visit

- Willingness to have facial exams, skin instrumentation measurements, and digital
photos performed on the face.

Exclusion Criteria:

- Individuals with active symptoms of allergy, cold sore or warts, active psoriasis or
eczema, rosacea, sunburn, open wounds, neurotic excoriations, excessive scarring,
tattoos, or other skin conditions in the test area

- Uncontrolled disease such as diabetes, hypertension, hyper or hypo-thyroidism, active
hepatitis, immune deficiency, or autoimmune

- Individuals who have a pre-existing or dormant dermatologic condition (e.g. history of
severe psoriasis, atopic dermatitis, rosacea, skin cancer, etc.)

- Individuals who have had a blepharoplasty procedure or any other surgery in proximity
or affecting the test area

- Individuals with recent procedures/surgeries (less than 6 months) on the eye bulb

- Individuals with permanent makeup around the eye area

- Chemical peel, microdermabrasion, microneedling, or dermaplaning in the previous 4
weeks

- Latisse, Revitalash, or other lash enhancement stimulators in the previous 1 month

- Retin-A®, Retin-A Micro®, Renova®, Avita®, Tazorac®, Avage® or Differin® or other
similar prescription drugs within the previous 3 months

- Cosmetic injections (filler and/or toxins, i.e.Juvederm, Radiesse, Botox, etc.), non-
ablative laser or fractional laser resurfacing in the previous 12 months

- Accutane® or other oral retinoid, Ablative procedures (i.e. laser, chemical) in the
previous 12 months

- Individuals who have any planned surgeries or procedures during the study.