Web-based Weight Loss Intervention
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 2/9/2018 |
| Start Date: | December 27, 2017 |
| End Date: | January 8, 2019 |
Excess weight is a major risk factor underlying leading causes of death globally, including
cardiovascular disease, type 2 diabetes, and some cancers. Among participants assigned to the
same lifestyle intervention arms in prior weight loss randomized controlled trials, large
inter-individual differences in weight loss success have been observed, ranging from >50lbs
of weight loss to >10lbs of weight gain. Both genetic and non-genetic factors underlying
differential adherence and weight loss success are poorly understood.
cardiovascular disease, type 2 diabetes, and some cancers. Among participants assigned to the
same lifestyle intervention arms in prior weight loss randomized controlled trials, large
inter-individual differences in weight loss success have been observed, ranging from >50lbs
of weight loss to >10lbs of weight gain. Both genetic and non-genetic factors underlying
differential adherence and weight loss success are poorly understood.
23andMe aims to recruit 91,227 adults to participate in a web-based weight loss intervention.
Primary aims include: a.) to confirm whether AG/GG individuals at MTIF3 rs1885988 lose more
weight on lifestyle interventions; and b.) to test the performance of a randomized controlled
trial vs. self-selection study design in terms of weight loss, drop-outs, and adherence.
Secondary (exploratory) analyses will focus on discovery of genetic and non-genetic
predictors of weight loss success overall, and examination of potential interactions by
intervention type. Web-administered intervention content, videos, and forums will be surfaced
to participants every two weeks, and self-reported surveys will be surfaced weekly for the
active intervention duration.
Primary aims include: a.) to confirm whether AG/GG individuals at MTIF3 rs1885988 lose more
weight on lifestyle interventions; and b.) to test the performance of a randomized controlled
trial vs. self-selection study design in terms of weight loss, drop-outs, and adherence.
Secondary (exploratory) analyses will focus on discovery of genetic and non-genetic
predictors of weight loss success overall, and examination of potential interactions by
intervention type. Web-administered intervention content, videos, and forums will be surfaced
to participants every two weeks, and self-reported surveys will be surfaced weekly for the
active intervention duration.
Inclusion Criteria:
- US-based men and women in self-reported 'good' or better health
- Consented to participate in research
- BMI 25-40 kg/m2
- Not actively on a weight loss plan
- Willing and able to modify eating and physical activity patterns
- Not under a doctor's care for a serious medical condition
Exclusion Criteria:
- Are pregnant, lactating, within 6 months postpartum, or planning to become pregnant in
the next 6 months
- Have diabetes (type 1 or 2) or are on hypoglycemic medications
- Had a heart attack or stroke within the past year
- Are unable or unwilling to follow a physical activity or diet intervention due to a
medical condition or doctor's orders
- Have an eating disorder
- Have severe depression, anxiety, or other psychiatric conditions
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