Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 8/22/2018 |
| Start Date: | December 21, 2017 |
| End Date: | August 2021 |
| Contact: | Marc W Slutzky, MD, PhD |
| Email: | mslutzky@northwestern.edu |
| Phone: | 3125034653 |
The purpose of the study is to explore the feasibility of using a wearable device, called a
myoelectric-computer interface (MCI), to improve arm movement in people who have had a
stroke.
Impaired arm movement after stroke is caused not just by weakness, but also by impaired
coordination between joints due to abnormal co-activation of muscles. These abnormal
co-activation patterns are thought to be due to abnormal movement planning.The MCI aims to
reduce abnormal co-activation by providing feedback about individual muscle activations.
This randomized, controlled, blinded study will test the home use of an MCI in chronic and
acute stroke survivors.
myoelectric-computer interface (MCI), to improve arm movement in people who have had a
stroke.
Impaired arm movement after stroke is caused not just by weakness, but also by impaired
coordination between joints due to abnormal co-activation of muscles. These abnormal
co-activation patterns are thought to be due to abnormal movement planning.The MCI aims to
reduce abnormal co-activation by providing feedback about individual muscle activations.
This randomized, controlled, blinded study will test the home use of an MCI in chronic and
acute stroke survivors.
Inclusion Criteria:
Chronic stroke participants
- Hemiparesis from first ever stroke at least 6 months prior to screening
- Severe motor impairment (FMA of 7-30)
- At least some voluntary shoulder and elbow muscle activation.
Acute stroke participants
- Hemiparesis from first ever stroke within the past 7 days
- Severe motor impairment (FMA of 3-20)
- At least some voluntary shoulder and elbow muscle activation.
Exclusion Criteria:
- Cognitive impairment with at least moderately impaired attention, or unable to follow
instructions of the MCI task
- Visual impairment (such as hemianopia) preventing full view of the screen
- Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the
NIH Stroke Scale Extinction and Inattention subtest).
- Participation in another study on the affected arm within 6 weeks of enrollment or any
pharmacological study
- Inability to understand or follow commands in English due to aphasia or other reason
- Diffuse or multifocal infarcts
- Substantial arm pain preventing participation for 90 minutes a day
- New spasticity treatment (pharmacological or Botox)
- Invasive thrombolysis or clot retrieval therapy (for acute stroke participants)
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