Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

The normal aging has a devastating effect on our cognitive ability to learn and remember, on
the speed with which the investigators process information, and on our ability to reason. By
2050, nearly 14 million individuals in the US will be living with Alzheimer's disease (AD),
up from 5 million in 2013. AD is the most common cause of dementia, resulting in the loss of
cognitive functions such as memory, reasoning, language, and cognitive, social, physical, and
emotional control, to the extent that losses interfere with activities of daily living and
necessitate continuous monitoring and care. Many studies now show that the processing
machinery of the brain is plastic and remodeled throughout life by learning and experience,
enabling the strengthening of cognitive skills or abilities. Research has shown that brief,
daily computerized cognitive training that is sufficiently challenging, goal-directed and
adaptive enables intact brain structures to restore balance in attention and compensate for
disruptions in cognitive functioning. The study aims to understand how our computer program
can affect cognition and attention in those with aging brain.

Inclusion Criteria:

1. Age 65-79 years at the time of consent

2. Fluent English speakers, to ensure reasonable results neuropsychological assessments

3. Adequate sensorimotor capacity to perform the program, including visual capacity
adequate to read from a computer screen at a normal viewing distance, auditory
capacity adequate to understand normal speech, and motor capacity adequate to control
a computer mouse

4. No evidence of dementia as indicated by Montreal Cognitive Assessment (MoCA) scores
>25

Exclusion Criteria:

1. Diagnosis with Alzheimer's disease or related dementias

2. Requiring caregiver assistance in dressing/personal hygiene

3. Medical conditions predisposing to imminent functional decline

4. Recent participation of computer-delivered cognitive training

5. Diagnosis of an illness or condition with known cognitive consequences (e.g.,
schizophrenia, bipolar disorder, cancer, multiple sclerosis) will be excluded due to
the confound with cognitive impairment from normal aging.

6. Uncorrectable acuity greater than 20/40

7. Self-reported cardiovascular disease

8. Claustrophobia or any other contraindication to MRI scanning

9. Inability to complete a 1-hour MRI

10. Any implanted devices above the waist (e.g., cardiac pacemaker or auto-defibrillators,
neural pacemaker, aneurysm clips, cochlear implant, metallic bodies in the eye or
central nervous system, any form of wires or metal devices that may concentrate radio
frequency fields)

11. History of brain surgery; removal of brain tissue; or history of stroke.